Fenproporex produces amphetamine as a metabolite[4][5] and was withdrawn in many countries following problems with abuse,[6] but it is still prescribed in some countries. It is sometimes combined with benzodiazepines, antidepressants, and other compounds to create a version of the "rainbow diet pill".[7][8][9]
Fenproporex has never been approved by the US Food and Drug Administration (FDA) for sale in the US due to lack of efficacy and safety data. However, in March 2009, the FDA warned consumers that it has been detected as an unlabeled component of diet pills available over the Internet.[10] Fenproporex is designated a Schedule IV controlled substance in the US pursuant to the Controlled Substances Act.[11]
^Warembourg H, Jaillard J. Clinical experimentation with fenproporex in the treatment of obesity. Apropos of 40 cases. (French). Journal de la Faculte de médecine et de pharmacie de l'Universite de Lille. 1968 Mar;13(3):Suppl:273-6.
^Tognoni G, Morselli PL, Garattini S (October 1972). "Amphetamine concentrations in rat brain and human urine after fenproporex administration". European Journal of Pharmacology. 20 (1): 125–6. doi:10.1016/0014-2999(72)90227-0. PMID4637940.
^Cody JD (December 1993). "Metabolic Precursors to Amphetamine and Methamphetamine". Forensic Science Review. 5 (2): 109–27. PMID26270078.
^Pélissier-Alicot AL, Piercecchi-Marti MD, Bartoli C, Kuhlmann E, Coiffait PE, Sanvoisin A, et al. (March 2006). "Abusive prescription of psychostimulants: a study of two cases". Journal of Forensic Sciences. 51 (2): 407–10. doi:10.1111/j.1556-4029.2006.00078.x. PMID16566781. S2CID39460850.
^Cohen PA, McCormick D, Casey C, Dawson GF, Hacker KA (June 2009). "Imported compounded diet pill use among Brazilian women immigrants in the United States". Journal of Immigrant and Minority Health. 11 (3): 229–36. doi:10.1007/s10903-007-9099-x. PMID18066718. S2CID8730835.