Fentiazac

Fentiazac
Clinical data
Trade names	Norvedan
AHFS/Drugs.com	International Drug Names
ATC code	M02AA14 (WHO) ;
Identifiers
	IUPAC name 2-[4-(4-chlorophenyl)-2-phenyl-1,3-thiazol-5-yl]acetic acid;
CAS Number	18046-21-4 ;
PubChem CID	28871;
ChemSpider	26854 ;
UNII	0YHF6E6NLS;
KEGG	D01975 ;
ChEMBL	ChEMBL589092 ;
CompTox Dashboard (EPA)	DTXSID8023050 ;
ECHA InfoCard	100.038.129
Chemical and physical data
Formula	C17H12ClNO2S
Molar mass	329.80 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	162–163 °C (324–325 °F)
	SMILES c1ccc(cc1)c2nc(c(s2)CC(=O)O)c3ccc(cc3)Cl;
	InChI InChI=1S/C17H12ClNO2S/c18-13-8-6-11(7-9-13)16-14(10-15(20)21)22-17(19-16)12-4-2-1-3-5-12/h1-9H,10H2,(H,20,21) ; Key:JIEKMACRVQTPRC-UHFFFAOYSA-N ;
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Fentiazac is a thiazole-based nonsteroidal anti-inflammatory drug (NSAID) developed for use in joint and muscular pain.^[1] Like most other NSAIDs, it acts through inhibition of prostaglandin synthesis, via non-selective inhibition of both COX-1 and COX-2. First described in 1974, it was synthesized using the Hantzsch thiazole synthesis.^[2]

Fentiazac was marketed under the trade-name Norvedan (among others), but its market status is currently unknown and assumed to be discontinued.^[3]

^ Lombardino JG (1985). Nonsteroidal antiinflammatory drugs. Vol. 247. New York: Wiley. p. 285. ISBN 978-0-471-89803-0.
^ Brown K, Cater DP, Cavalla JF, Green D, Newberry RA, Wilson AB (November 1974). "Nonsteroidal antiinflammatory agents. 1.2,4-Diphenylthiazole-5-acetic acid and related compounds". Journal of Medicinal Chemistry. 17 (11): 1177–1181. doi:10.1021/jm00257a010. PMID 4414839.
^ "FENTIAZAC". NCATS Inxight Drugs. National Center for Advancing Translational Sciences (NCATS); U.S. National Institutes of Health. Retrieved 2023-06-08.

[1] Lombardino JG (1985). Nonsteroidal antiinflammatory drugs. Vol. 247. New York: Wiley. p. 285. ISBN 978-0-471-89803-0.

[2] Brown K, Cater DP, Cavalla JF, Green D, Newberry RA, Wilson AB (November 1974). "Nonsteroidal antiinflammatory agents. 1.2,4-Diphenylthiazole-5-acetic acid and related compounds". Journal of Medicinal Chemistry. 17 (11): 1177–1181. doi:10.1021/jm00257a010. PMID 4414839.

[3] "FENTIAZAC". NCATS Inxight Drugs. National Center for Advancing Translational Sciences (NCATS); U.S. National Institutes of Health. Retrieved 2023-06-08.

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