Feprosidnine, sold under the brand name Sydnophen, is a stimulant drug which was developed in the USSR in the 1970s.[1][2] It is structurally related to another Russian drug mesocarb but unlike mesocarb, was withdrawn earlier from production. In comparison with mesocarb it has own antidepressant activity, which makes it useful in treating depressions. Indications of feprosidnine included apathic, asthenic depressions, fatigue, apathic syndrome, narcolepsy and other similar conditions. Therapeutic range of doses: 10-50mg a day.
Sydnophen has multiple mechanisms of action, the relative importance of which has not been clearly established. Effects on the body include reversible monoamine oxidase inhibition, cholinergic,[3]adrenergic,[4]opioid[5] and nitric oxide donating[6] actions, all of which may contribute to its pharmacological effects to some extent.
^Veksler IG, Riabukha VN, Balitskiĭ KP, Al'tshuler RA, Mashkovskiĭ MD (1980). "[Immunostimulating and antitumor action of psychotropic preparations of the sydnonimine series]". Farmakologiia I Toksikologiia (in Russian). 43 (3): 349–52. PMID7449977.
^Koniaeva EI, Beketov AI (1987). "[Effect of caffeine and sidnofen on the blood supply of the brain, kidneys and hindlimbs during antiorthostatism]". Farmakologiia I Toksikologiia (in Russian). 50 (3): 39–42. PMID3609274.
^Samonina GE, Mandriko EV (April 1989). "[Peripheral cholinolytic action--one of the effects of sidnofen]". Biulleten' Eksperimental'noi Biologii I Meditsiny (in Russian). 107 (4): 449–51. PMID2720163.
^Babskaia NE (1992). "[Sidnofen-dependent pre- and postsynaptic activation of peripheral adrenergic transmission]". Eksperimental'naia i Klinicheskaia Farmakologiia (in Russian). 55 (5): 21–5. PMID1339046.
^D'iakonova TL, Samonina GE (1994). "[The naloxone-dependent effects of the psychostimulant sidnofen: a study on identified neurons of the snail]". Zhurnal Vysshei Nervnoi Deiatelnosti Imeni I P Pavlova (in Russian). 44 (4–5): 786–95. PMID7810220.
^Arzamastsev AP, Severina IS, Grigor'ev NB, Granik VG (2003). "[Exogenous donors of nitric oxide and inhibitors of NO-synthase (chemical aspects)]". Vestnik Rossiiskoi Akademii Meditsinskikh Nauk (in Russian) (12): 88–95. PMID14724985.