Ferritin light chain

FTL
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2FFX, 2FG4, 2FG8, 3KXU
Identifiers
Aliases	FTL, LFTD, NBIA3, ferritin, light polypeptide, ferritin light chain
External IDs	OMIM: 134790; MGI: 5434102; HomoloGene: 79330; GeneCards: FTL; OMA:FTL - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	48,966,879 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; blood; ; gallbladder; ; upper lobe of left lung; ; right lung; ; islet of Langerhans; ; subcutaneous adipose tissue; ; spleen; ; monocyte; ; Descending thoracic aorta;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	iron ion binding; protein binding; ferric iron binding; metal ion binding; identical protein binding; ferroxidase activity; ferrous iron binding;
Cellular component	cytosol; extracellular exosome; intracellular ferritin complex; membrane; extracellular region; azurophil granule lumen; autolysosome; cytoplasm;
Biological process	iron ion homeostasis; iron ion transport; cellular iron ion homeostasis; intracellular sequestering of iron ion; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	2512
	434624
	ENSG00000087086
	n/a
	P02792
	n/a
	NM_000146
	n/a
	NP_000137
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Ferritin light chain is a protein that in humans is encoded by the FTL gene.^[4]^[5]^[6] Ferritin is the major protein responsible for storing intracellular iron in prokaryotes and eukaryotes. It is a heteropolymer consisting of 24 subunits, heavy and light ferritin chains.^[6] This gene has multiple pseudogenes.^[6]

It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these assisted reproductive technologies.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000087086 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lebo RV, Kan YW, Cheung MC, Jain SK, Drysdale J (December 1985). "Human ferritin light chain gene sequences mapped to several sorted chromosomes". Hum. Genet. 71 (4): 325–8. doi:10.1007/BF00388458. PMID 3000916. S2CID 2574558.
^ Gasparini P, Calvano S, Memeo E, Bisceglia L, Zelante L (Apr 1997). "Assignment of ferritin L gene (FTL) to human chromosome band 19q13.3 by in situ hybridization". Ann. Genet. 40 (4): 227–8. PMID 9526618.
^ ^a ^b ^c "FTL ferritin, light polypeptide". National Center for Biotechnology Information. 5 July 2009. Retrieved 20 July 2009.
^ Zhang Y, Zhang YL, Feng C, Wu YT, Liu AX, Sheng JZ, Cai J, Huang HF (October 2008). "Comparative proteomic analysis of human placenta derived from assisted reproductive technology". Proteomics. 8 (20): 4344–56. doi:10.1002/pmic.200800294. PMID 18792929. S2CID 206362532.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000087086 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3000916-4] Lebo RV, Kan YW, Cheung MC, Jain SK, Drysdale J (December 1985). "Human ferritin light chain gene sequences mapped to several sorted chromosomes". Hum. Genet. 71 (4): 325–8. doi:10.1007/BF00388458. PMID 3000916. S2CID 2574558.

[pmid9526618-5] Gasparini P, Calvano S, Memeo E, Bisceglia L, Zelante L (Apr 1997). "Assignment of ferritin L gene (FTL) to human chromosome band 19q13.3 by in situ hybridization". Ann. Genet. 40 (4): 227–8. PMID 9526618.

[entrez-6] "FTL ferritin, light polypeptide". National Center for Biotechnology Information. 5 July 2009. Retrieved 20 July 2009.

[zhang-7] Zhang Y, Zhang YL, Feng C, Wu YT, Liu AX, Sheng JZ, Cai J, Huang HF (October 2008). "Comparative proteomic analysis of human placenta derived from assisted reproductive technology". Proteomics. 8 (20): 4344–56. doi:10.1002/pmic.200800294. PMID 18792929. S2CID 206362532.

[1]

[2]

[3]

[4]

[5]

[6]

[7]