Ferroportin

SLC40A1
Identifiers
AliasesSLC40A1, IREG1, MST079, MSTP079, solute carrier family 40 member 1, MTP1, SLC11A3, FPN1, HFE4
External IDsOMIM: 604653; MGI: 1315204; HomoloGene: 40959; GeneCards: SLC40A1; OMA:SLC40A1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014585

NM_016917

RefSeq (protein)

NP_055400

NP_058613

Location (UCSC)Chr 2: 189.56 – 189.58 MbChr 1: 45.95 – 45.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ferroportin-1, also known as solute carrier family 40 member 1 (SLC40A1) or iron-regulated transporter 1 (IREG1), is a protein that in humans is encoded by the SLC40A1 gene.[5] Ferroportin is a transmembrane protein that transports iron from the inside of a cell to the outside of the cell. Ferroportin is the only known iron exporter.[6]

After dietary iron is absorbed into the cells of the small intestine, ferroportin allows that iron to be transported out of those cells and into the bloodstream. Fpn also mediates the efflux of iron recycled from macrophages resident in the spleen and liver.[7]

Ferroportin is regulated by hepcidin, a hormone produced by the liver; hepcidin binds to Fpn and limits its iron-efflux activity, thereby reducing iron delivery to the blood plasma.[8] Therefore, the interaction between Fpn and hepcidin controls systemic iron homeostasis.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138449Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025993Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Donovan A, Brownlie A, Zhou Y, Shepard J, Pratt SJ, Moynihan J, et al. (February 2000). "Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter". Nature. 403 (6771): 776–781. Bibcode:2000Natur.403..776D. doi:10.1038/35001596. PMID 10693807. S2CID 4429026.
  6. ^ Ward DM, Kaplan J (September 2012). "Ferroportin-mediated iron transport: expression and regulation". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1823 (9): 1426–1433. doi:10.1016/j.bbamcr.2012.03.004. PMC 3718258. PMID 22440327.
  7. ^ Canonne-Hergaux F, Donovan A, Delaby C, Wang HJ, Gros P (January 2006). "Comparative studies of duodenal and macrophage ferroportin proteins". American Journal of Physiology. Gastrointestinal and Liver Physiology. 290 (1): G156–G163. doi:10.1152/ajpgi.00227.2005. PMID 16081760.
  8. ^ Cite error: The named reference pmid15514116 was invoked but never defined (see the help page).