Fibrin glue

Fibrin glue
Fibrin glue applied after drying the scleral bed in an intraocular lens operation
Combination of
FibrinogenGlycoprotein
ThrombinCoagulation factor
Clinical data
Trade namesArtiss, Evicel, Tisseel, others
AHFS/Drugs.comProfessional Drug Facts
License data
Pregnancy
category
Routes of
administration		Topical
ATC code
Legal status
Legal status
Identifiers
KEGG

Fibrin glue (also called fibrin sealant) is a surgical formulation used to create a fibrin clot for hemostasis, cartilage repair surgeries or wound healing. It contains separately packaged human fibrinogen and human thrombin.[15][16][17][18][19][20][21][22][23][24]

  1. ^ a b "VeraSeal". Therapeutic Goods Administration (TGA). 12 November 2021. Retrieved 28 December 2021.
  2. ^ "Updates to the Prescribing Medicines in Pregnancy database". Therapeutic Goods Administration (TGA). 12 May 2022. Retrieved 13 May 2022.
  3. ^ "AusPAR: Human Fibrinogen / Human Thrombin". Therapeutic Goods Administration (TGA). 29 June 2022. Retrieved 17 July 2022.
  4. ^ "Health product highlights 2021: Annexes of products approved in 2021". Health Canada. 3 August 2022. Retrieved 25 March 2024.
  5. ^ "TachoSil sealant matrix - Summary of Product Characteristics (SmPC)". (emc). 31 January 2020. Archived from the original on 10 July 2020. Retrieved 10 July 2020.
  6. ^ "Tisseel Ready to use Solutions for Sealant - Summary of Product Characteristics (SmPC)". (emc). 30 December 2019. Retrieved 10 July 2020.
  7. ^ "Artiss Solutions for Sealant - Summary of Product Characteristics (SmPC)". (emc). 29 January 2019. Retrieved 10 July 2020.
  8. ^ Cite error: The named reference FDA Evicel was invoked but never defined (see the help page).
  9. ^ "Vistaseal". U.S. Food and Drug Administration (FDA). 1 October 2024. Retrieved 2 October 2024.
  10. ^ "Artiss Fibrin Sealant- fibrinogen human, human thrombin solution". DailyMed. 9 June 2022. Retrieved 2 October 2024.
  11. ^ "Tisseel Fibrin Sealant- fibrinogen human, human thrombin kit; Tisseel Fibrin Sealant- fibrinogen human, human thrombin solution". DailyMed. 26 December 2019. Retrieved 2 October 2024.
  12. ^ "TachoSil". U.S. Food and Drug Administration. 1 October 2024. Retrieved 2 October 2024.
  13. ^ Cite error: The named reference Evicel EPAR was invoked but never defined (see the help page).
  14. ^ "Veraseal EPAR". European Medicines Agency (EMA). 10 November 2017. Retrieved 13 September 2024.
  15. ^ Irwin RM, Bonassar LJ, Cohen I, Matuska AM, Commins J, Cole B, et al. (8 November 2019). "The clot thickens: Autologous and allogeneic fibrin sealants are mechanically equivalent in an ex vivo model of cartilage repair". PLOS ONE. 14 (11): e0224756. Bibcode:2019PLoSO..1424756I. doi:10.1371/journal.pone.0224756. PMC 6839864. PMID 31703078.
  16. ^ Shah NV, Meislin R (December 2013). "Current state and use of biological adhesives in orthopedic surgery". Orthopedics. 36 (12): 945–956. doi:10.3928/01477447-20131120-09. PMID 24579215.
  17. ^ Smith BL, Matuska AM, Greenwood VL, Gilat R, Wijdicks CA, Cole BJ (15 April 2022). "Autologous Fibrin Sealants Have Comparable Graft Fixation to an Allogeneic Sealant in a Biomechanical Cadaveric Model of Chondral Defect Repair". Arthroscopy, Sports Medicine, and Rehabilitation. 4 (3): e1075–e1082. doi:10.1016/j.asmr.2022.03.003. ISSN 2666-061X. PMC 9210474. PMID 35747626. S2CID 248208731.
  18. ^ Atrah HI (April 1994). "Fibrin glue". BMJ. 308 (6934): 933–934. doi:10.1136/bmj.308.6934.933. PMC 2539755. PMID 8173397.
  19. ^ Thompson DF, Letassy NA, Thompson GD (December 1988). "Fibrin glue: a review of its preparation, efficacy, and adverse effects as a topical hemostat". Drug Intelligence & Clinical Pharmacy. 22 (12): 946–952. doi:10.1177/106002808802201203. PMID 2468466. S2CID 37017252.
  20. ^ "Fibrin Glue for Anal Fistula - Digestive Disorders / Gastroenterology". MedHelp.
  21. ^ Shinohara K, Kobayashi E, Yoshida T, Toyama N, Kiyozaki H, Fujimura A, et al. (1998). "Effect of fibrin glue on small and large bowel anastomoses in the rat". European Surgical Research. 30 (1): 8–12. doi:10.1159/000008552. PMID 9493689. S2CID 46792418.
  22. ^ Spotnitz WD, Mintz PD, Avery N, Bithell TC, Kaul S, Nolan SP (August 1987). "Fibrin glue from stored human plasma. An inexpensive and efficient method for local blood bank preparation". The American Surgeon. 53 (8): 460–462. PMID 2440358.
  23. ^ Saxena S, Jain P, Shukla J (2003). "Preparation of two component Fibrin Glue and its clinical evaluation in skin grafts and flaps". Indian J Plast Surg. 36 (1): 14–17. doi:10.1055/s-0043-1778572.
  24. ^ Mücke T, Wolff KD (2009). "Performing microvascular anastomosis with fibrin glue--faster, easier, and more reliable?". Microsurgery. 29 (1): 80–81. doi:10.1002/micr.20556. PMID 18946885. S2CID 31854904.