Fibroblast activation protein alpha (FAP-alpha) also known as prolyl endopeptidase FAP is an enzyme that in humans is encoded by the FAP gene.[5]
Prolyl endopeptidase FAP is a 170 kDa membrane-bound gelatinase. It was independently identified as a surface glycoprotein recognized by the F19 monoclonal antibody in activated fibroblasts[6] and a Surface Expressed Protease (seprase) in invasive melanoma cells.[7][8]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000078098 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000392 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Cite error: The named reference
entrezwas invoked but never defined (see the help page). - ^ Garin-Chesa P, Old LJ, Rettig WJ (September 1990). "Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers". Proceedings of the National Academy of Sciences of the United States of America. 87 (18): 7235–9. Bibcode:1990PNAS...87.7235G. doi:10.1073/pnas.87.18.7235. PMC 54718. PMID 2402505.
- ^ Monsky WL, Lin CY, Aoyama A, Kelly T, Akiyama SK, Mueller SC, Chen WT (November 1994). "A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells". Cancer Research. 54 (21): 5702–10. PMID 7923219.
- ^ Aoyama A, Chen WT (November 1990). "A 170-kDa membrane-bound protease is associated with the expression of invasiveness by human malignant melanoma cells". Proceedings of the National Academy of Sciences of the United States of America. 87 (21): 8296–300. Bibcode:1990PNAS...87.8296A. doi:10.1073/pnas.87.21.8296. PMC 54942. PMID 2172980.