Fibroblast growth factor receptor 1

FGFR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AGW, 1CVS, 1EVT, 1FGI, 1FGK, 1FQ9, 1XR0, 2CR3, 2FGI, 3C4F, 3DPK, 3GQI, 3GQL, 3JS2, 3KRJ, 3KRL, 3KXX, 3KY2, 3RHX, 3TT0, 4F63, 4F64, 4F65, 4NK9, 4NKA, 4NKS, 4RWI, 4RWJ, 4RWK, 4RWL, 4UWY, 4WUN, 5AM6, 5AM7, 4ZSA, 5A4C, 4UWB, 4UWC, 5A46, 5FLF, 5EW8, 5B7V
Identifiers
Aliases	FGFR1, BFGFR, CD331, CEK, FGFBR, FGFR-1, FLG, FLT-2, FLT2, HBGFR, HH2, HRTFDS, KAL2, N-SAM, OGD, bFGF-R-1, ECCL, fibroblast growth factor receptor 1
External IDs	OMIM: 136350; MGI: 95522; HomoloGene: 69065; GeneCards: FGFR1; OMA:FGFR1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p11.23 Start 38,400,215 bp[1] End 38,468,834 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 A2|8 14.12 cM Start 26,003,670 bp[2] End 26,065,734 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell stromal cell of endometrium Achilles tendon right ovary paraflocculus of cerebellum left ovary right coronary artery left uterine tube right hemisphere of cerebellum Descending thoracic aorta Top expressed in molar decidua body of femur pontine nuclei gastrula ventricular zone lip ankle calvaria median eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function kinase activity transmembrane receptor protein tyrosine kinase activity ATP binding protein kinase activity transferase activity protein homodimerization activity protein binding nucleotide binding identical protein binding fibroblast growth factor binding fibroblast growth factor-activated receptor activity heparin binding 1-phosphatidylinositol-3-kinase activity protein tyrosine kinase activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity receptor-receptor interaction receptor tyrosine kinase transmembrane signaling receptor activity SH2 domain binding Cellular component cytoplasm cytosol membrane extracellular region nucleus receptor complex integral component of plasma membrane cytoplasmic vesicle plasma membrane integral component of membrane nucleolus Biological process skeletal system development ureteric bud development fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development positive regulation of endothelial cell chemotaxis to fibroblast growth factor positive regulation of MAP kinase activity positive regulation of phospholipase C activity regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling positive regulation of cardiac muscle cell proliferation mesenchymal cell differentiation positive regulation of mesenchymal cell proliferation angiogenesis orbitofrontal cortex development positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway branching involved in salivary gland morphogenesis regulation of transcription, DNA-templated blood vessel morphogenesis regulation of extrinsic apoptotic signaling pathway in absence of ligand lung development in utero embryonic development cell maturation negative regulation of gene expression transcription, DNA-templated positive regulation of cell cycle embryonic limb morphogenesis positive regulation of neuron differentiation protein autophosphorylation auditory receptor cell development positive regulation of MAPK cascade paraxial mesoderm development chondrocyte differentiation organ induction phosphorylation ventricular zone neuroblast division skeletal system morphogenesis neuron migration outer ear morphogenesis negative regulation of transcription by RNA polymerase II middle ear morphogenesis regulation of gene expression phosphatidylinositol-mediated signaling midbrain development chordate embryonic development hearing salivary gland morphogenesis generation of neurons MAPK cascade regulation of lateral mesodermal cell fate specification positive regulation of phospholipase activity brain development regulation of cell population proliferation inner ear morphogenesis positive regulation of neuron projection development regulation of cell differentiation positive regulation of phosphatidylinositol 3-kinase signaling peptidyl-tyrosine phosphorylation lung-associated mesenchyme development cell migration phosphatidylinositol-3-phosphate biosynthetic process phosphatidylinositol phosphate biosynthetic process protein phosphorylation fibroblast growth factor receptor signaling pathway positive regulation of cell population proliferation positive regulation of parathyroid hormone secretion negative regulation of fibroblast growth factor production vitamin D3 metabolic process regulation of phosphorus metabolic process positive regulation of mitotic cell cycle DNA replication positive regulation of protein kinase B signaling regulation of phosphate transport positive regulation of blood vessel endothelial cell migration positive regulation of vascular endothelial cell proliferation ear development negative regulation of signal transduction cell differentiation negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade transmembrane receptor protein tyrosine kinase signaling pathway nervous system development positive regulation of cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2260 14182 Ensembl ENSG00000077782 ENSMUSG00000031565 UniProt P11362 P16092 RefSeq (mRNA) NM_001174063 NM_001174064 NM_001174065 NM_001174066 NM_001174067 NM_015850 NM_023105 NM_023106 NM_023107 NM_023108 NM_023109 NM_023110 NM_023111 NM_032191 NM_001354367 NM_001354368 NM_001354369 NM_001354370 NM_001079908 NM_001079909 NM_010206 RefSeq (protein) NP_001167534 NP_001167535 NP_001167536 NP_001167537 NP_001167538 NP_056934 NP_075593 NP_075594 NP_075598 NP_001341296 NP_001341297 NP_001341298 NP_001341299 NP_001073377 NP_001073378 NP_034336 Location (UCSC) Chr 8: 38.4 – 38.47 Mb Chr 8: 26 – 26.07 Mb PubMed search [3] [4]
Wikidata
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Fibroblast growth factor receptor 1 (FGFR-1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome, and CD331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. FGFR-1 has been shown to be associated with Pfeiffer syndrome,^[5] and clonal eosinophilias.^[6]