Fibromodulin

FMOD
Identifiers
Aliases	FMOD, FM, SLRR2E, fibromodulin
External IDs	OMIM: 600245; MGI: 1328364; HomoloGene: 1530; GeneCards: FMOD; OMA:FMOD - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	203,351,758 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	133,976,015 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; tibia; ; cartilage tissue; ; right coronary artery; ; ascending aorta; ; Descending thoracic aorta; ; left coronary artery; ; popliteal artery; ; tibial arteries; ; synovial joint;
	Top expressed in
	calvaria; ; ciliary body; ; body of femur; ; ankle; ; skin of external ear; ; semi-lunar valve; ; aortic valve; ; ankle joint; ; iris; ; conjunctival fornix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	heparin binding; Roundabout binding; extracellular matrix structural constituent conferring compression resistance;
Cellular component	Golgi lumen; extracellular matrix; lysosomal lumen; extracellular space; extracellular region; collagen-containing extracellular matrix;
Biological process	transforming growth factor beta receptor complex assembly; keratan sulfate biosynthetic process; keratan sulfate catabolic process; axonogenesis; collagen fibril organization;
	Sources:Amigo / QuickGO
Orthologs
	2331
	14264
	ENSG00000122176
	ENSMUSG00000041559
	Q06828
	P50608
	NM_002023
	NM_021355
	NP_002014
	NP_067330
	Wikidata
View/Edit Human	View/Edit Mouse

Fibromodulin is a protein that in humans is encoded by the FMOD gene.^[5]^[6]

Fibromodulin is a 42kDa protein of a family of small interstitial leucine-rich repeat proteoglycans (SLRPs). It can have up to four N-linked keratan sulfate chains attached to the core protein within the leucine-rich region. It shares significant sequence homology with biglycan and decorin.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000122176 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041559 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sztrolovics R, Chen XN, Grover J, Roughley PJ, Korenberg JR (Mar 1995). "Localization of the human fibromodulin gene (FMOD) to chromosome 1q32 and completion of the cDNA sequence". Genomics. 23 (3): 715–7. doi:10.1006/geno.1994.1567. PMID 7851907.
^ "Entrez Gene: FMOD fibromodulin".
^ Antonsson P, Heinegård D, Oldberg A (1993). "Structure and deduced amino acid sequence of the human fibromodulin gene". Biochim Biophys Acta. 1174 (2): 204–6. doi:10.1016/0167-4781(93)90117-V. PMID 8357838.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000122176 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041559 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7851907-5] Sztrolovics R, Chen XN, Grover J, Roughley PJ, Korenberg JR (Mar 1995). "Localization of the human fibromodulin gene (FMOD) to chromosome 1q32 and completion of the cDNA sequence". Genomics. 23 (3): 715–7. doi:10.1006/geno.1994.1567. PMID 7851907.

[entrez-6] "Entrez Gene: FMOD fibromodulin".

[pmid8357838-7] Antonsson P, Heinegård D, Oldberg A (1993). "Structure and deduced amino acid sequence of the human fibromodulin gene". Biochim Biophys Acta. 1174 (2): 204–6. doi:10.1016/0167-4781(93)90117-V. PMID 8357838.

[1]

[2]

[3]

[4]

[5]

[6]

[7]