Fimbrin

PLS1
Identifiers
Aliases	PLS1, Fimbrin, plastin 1, DFNA76
External IDs	OMIM: 602734; MGI: 104809; HomoloGene: 68270; GeneCards: PLS1; OMA:PLS1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	142,713,664 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	95,727,364 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; jejunal mucosa; ; mucosa of ileum; ; mucosa of colon; ; mucosa of sigmoid colon; ; rectum; ; duodenum; ; palpebral conjunctiva; ; bronchial epithelial cell; ; mucosa of transverse colon;
	Top expressed in
	intestinal villus; ; ileum; ; jejunum; ; duodenum; ; large intestine; ; left colon; ; pyloric antrum; ; vestibular sensory epithelium; ; epithelium of small intestine; ; yolk sac;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; actin binding; structural constituent of cytoskeleton; metal ion binding; actin filament binding;
Cellular component	terminal web; extracellular exosome; brush border; cytoplasm; actin filament; actin filament bundle;
Biological process	intestinal D-glucose absorption; regulation of microvillus length; terminal web assembly; positive regulation of multicellular organism growth; actin filament bundle assembly; actin filament network formation; actin crosslink formation; positive regulation of protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	5357
	102502
	ENSG00000120756
	ENSMUSG00000049493
	Q14651
	Q3V0K9
	NM_001145319; NM_001172312; NM_002670
	NM_001033210
	NP_001138791; NP_001165783; NP_002661
	NP_001028382
	Wikidata
View/Edit Human	View/Edit Mouse

Fimbrin also known as is plastin 1 is a protein that in humans is encoded by the PLS1 gene.^[5] Fimbrin is an actin cross-linking protein important in the formation of filopodia.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000120756 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049493 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Plastin 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000120756 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049493 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Plastin 1".

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