| First Lady of the Syrian Arab Republic السيدة الأولى للجمهورية العربية السورية | |
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| Residence | People's Palace and Tishreen Palace, Damascus |
| Term length | Seven years, renewable once |
| Inaugural holder | Bahira al-Dalati (wife of Shukri al-Quwatli) |
| Formation | 17 August 1943 |
First Lady of Syria (Arabic: السيدة الأولى للجمهورية العربية السورية, romanized: al-Sayyidah al-Ūlá lil-Jumhūrīyah al-ʻArabīyah al-Sūrīyah) is a title attributed to the spouse of the incumbent president of Syria (currently Bashar al-Assad). For the past 51 years, two consecutive first ladies have come from the same ruling family, the Al-Assad family.