Fisetin

Fisetin
Names
	IUPAC name 3,3′,4′,7-Tetrahydroxyflavone
	Systematic IUPAC name 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one
	Other names 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxychromen-4-one; Cotinin (not to be confused with Cotinine); 5-Deoxyquercetin; Superfustel; Fisetholz; Fietin; Fustel; Fustet; Viset; Junger fustik
Identifiers
CAS Number	528-48-3 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:42567 ;
ChEMBL	ChEMBL31574 ;
ChemSpider	4444933 ;
DrugBank	DB07795 ;
ECHA InfoCard	100.007.669
IUPHAR/BPS	5182;
KEGG	C10041 ;
PubChem CID	5281614;
UNII	OO2ABO9578 ;
CompTox Dashboard (EPA)	DTXSID4022317 ;
	InChI InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H Key: XHEFDIBZLJXQHF-UHFFFAOYSA-N ; InChI=1/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H Key: XHEFDIBZLJXQHF-UHFFFAOYAQ;
	SMILES O=C1c3c(O/C(=C1/O)c2ccc(O)c(O)c2)cc(O)cc3;
Properties
Chemical formula	C15H10O6
Molar mass	286.2363 g/mol
Density	1.688 g/mL
Melting point	330 °C (626 °F; 603 K)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Fisetin (7,3′,4′-flavon-3-ol) is a plant flavonol from the flavonoid group of polyphenols.^[1] It can be found in many plants, where it serves as a yellow/ochre colouring agent. It is also found in many fruits and vegetables, such as strawberries, apples, persimmons, onions and cucumbers.^[2] Its chemical formula was first described by Austrian chemist Josef Herzig in 1891.^[3]

The biological activity of fisetin has been studied in many laboratory assays; like other polyphenols it has many activities.

^ Rodríguez-García C, Sánchez-Quesada C, Gaforio JJ (2019). "Dietary Flavonoids as Cancer Chemopreventive Agents: An Updated Review of Human Studies". Nutrients. 18 (5): 137. doi:10.3390/antiox8050137. PMC 6562590. PMID 31109072.
^ Sahu, Bidya Dhar; Kalvala, Anil Kumar; Koneru, Meghana; Kumar, Jerald Mahesh; Kuncha, Madhusudana; Rachamalla, Shyam Sunder; Sistla, Ramakrishna (September 3, 2014). "Ameliorative Effect of Fisetin on Cisplatin-Induced Nephrotoxicity in Rats via Modulation of NF-κB Activation and Antioxidant Defence". PLOS ONE. 9 (9): e105070. Bibcode:2014PLoSO...9j5070S. doi:10.1371/journal.pone.0105070. PMC 4153571. PMID 25184746.
^ Herzig, J. (1891). "Studien über Quercetin und seine Derivate, VII. Abhandlung" [Studies on Quercetin and its Derivatives, Treatise VII]. Monatshefte für Chemie (in German). 12 (1): 177–90. doi:10.1007/BF01538594. S2CID 197766725.

[pmid31109072-1] Rodríguez-García C, Sánchez-Quesada C, Gaforio JJ (2019). "Dietary Flavonoids as Cancer Chemopreventive Agents: An Updated Review of Human Studies". Nutrients. 18 (5): 137. doi:10.3390/antiox8050137. PMC 6562590. PMID 31109072.

[ReferenceA-2] Sahu, Bidya Dhar; Kalvala, Anil Kumar; Koneru, Meghana; Kumar, Jerald Mahesh; Kuncha, Madhusudana; Rachamalla, Shyam Sunder; Sistla, Ramakrishna (September 3, 2014). "Ameliorative Effect of Fisetin on Cisplatin-Induced Nephrotoxicity in Rats via Modulation of NF-κB Activation and Antioxidant Defence". PLOS ONE. 9 (9): e105070. Bibcode:2014PLoSO...9j5070S. doi:10.1371/journal.pone.0105070. PMC 4153571. PMID 25184746.

[3] Herzig, J. (1891). "Studien über Quercetin und seine Derivate, VII. Abhandlung" [Studies on Quercetin and its Derivatives, Treatise VII]. Monatshefte für Chemie (in German). 12 (1): 177–90. doi:10.1007/BF01538594. S2CID 197766725.

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