Flap structure-specific endonuclease 1

FEN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1U7B, 1UL1, 3Q8K, 3Q8L, 3Q8M, 3UVU, 5E0V
Identifiers
Aliases	FEN1, Flap endonuclease 1, flap structure-specific endonuclease 1, FEN-1, MF1, RAD2
External IDs	OMIM: 600393; MGI: 102779; HomoloGene: 3034; GeneCards: FEN1; OMA:FEN1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	61,797,238 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	10,181,533 bp
RNA expression pattern
	Top expressed in
	oocyte; ; amniotic fluid; ; paraflocculus of cerebellum; ; gingival epithelium; ; secondary oocyte; ; tendon of biceps brachii; ; gonad; ; trabecular bone; ; bone marrow; ; embryo;
	Top expressed in
	Paneth cell; ; ciliary body; ; primitive streak; ; retinal pigment epithelium; ; fetal liver hematopoietic progenitor cell; ; iris; ; cumulus cell; ; endothelial cell of lymphatic vessel; ; maxillary prominence; ; motor neuron;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; RNA-DNA hybrid ribonuclease activity; hydrolase activity, acting on ester bonds; nuclease activity; hydrolase activity; double-stranded DNA binding; catalytic activity; damaged DNA binding; double-stranded DNA exodeoxyribonuclease activity; protein binding; DNA binding; endonuclease activity; exonuclease activity; 5'-3' exonuclease activity; 5'-flap endonuclease activity; flap endonuclease activity; magnesium ion binding; manganese ion binding;
Cellular component	mitochondrion; nucleus; membrane; nucleoplasm; nucleolus; protein-containing complex;
Biological process	double-strand break repair via homologous recombination; double-strand break repair; memory; cellular response to DNA damage stimulus; UV protection; DNA replication; DNA repair; RNA phosphodiester bond hydrolysis, endonucleolytic; DNA replication, removal of RNA primer; positive regulation of sister chromatid cohesion; nucleic acid phosphodiester bond hydrolysis; telomere maintenance via semi-conservative replication; base-excision repair; apoptotic DNA fragmentation; retina development in camera-type eye;
	Sources:Amigo / QuickGO
Orthologs
	2237
	14156
	ENSG00000168496
	ENSMUSG00000024742
	P39748
	P39749
	NM_004111
	NM_001271614; NM_001271615; NM_007999
	NP_004102
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Flap endonuclease 1 is an enzyme that in humans is encoded by the FEN1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168496 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024742 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hiraoka LR, Harrington JJ, Gerhard DS, Lieber MR, Hsieh CL (January 1995). "Sequence of human FEN-1, a structure-specific endonuclease, and chromosomal localization of the gene (FEN1) in mouse and human". Genomics. 25 (1): 220–225. doi:10.1016/0888-7543(95)80129-A. PMID 7774922.
^ "Entrez Gene: FEN1 flap structure-specific endonuclease 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168496 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024742 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7774922-5] Hiraoka LR, Harrington JJ, Gerhard DS, Lieber MR, Hsieh CL (January 1995). "Sequence of human FEN-1, a structure-specific endonuclease, and chromosomal localization of the gene (FEN1) in mouse and human". Genomics. 25 (1): 220–225. doi:10.1016/0888-7543(95)80129-A. PMID 7774922.

[entrez-6] "Entrez Gene: FEN1 flap structure-specific endonuclease 1".

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