Flavin containing monooxygenase 1

FMO1
Identifiers
Aliases	FMO1, flavin containing monooxygenase 1, flavin containing dimethylaniline monoxygenase 1
External IDs	OMIM: 136130; MGI: 1310002; HomoloGene: 55520; GeneCards: FMO1; OMA:FMO1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q24.3 Start 171,248,471 bp[1] End 171,285,978 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H2.1|1 70.34 cM Start 162,657,130 bp[2] End 162,694,179 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney tubule glomerulus metanephric glomerulus human kidney mucosa of ileum parietal pleura mucosa of paranasal sinus renal medulla oral cavity skin of thigh Top expressed in right kidney human kidney yolk sac gastrula proximal tubule right lung tunica adventitia of aorta brown adipose tissue right lung lobe cardiac muscle tissue of left ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity N,N-dimethylaniline monooxygenase activity NADP binding flavin adenine dinucleotide binding monooxygenase activity protein binding Cellular component organelle membrane integral component of membrane endoplasmic reticulum lumen endoplasmic reticulum membrane endoplasmic reticulum membrane intracellular membrane-bounded organelle Biological process response to osmotic stress xenobiotic metabolic process toxin metabolic process response to lipopolysaccharide NADPH oxidation organic acid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2326 14261 Ensembl ENSG00000010932 ENSMUSG00000040181 UniProt Q01740 P50285 RefSeq (mRNA) NM_001282692 NM_001282693 NM_001282694 NM_002021 NM_010231 NM_001330291 NM_001330318 RefSeq (protein) NP_001269621 NP_001269622 NP_001269623 NP_002012 NP_001317220 NP_001317247 NP_034361 Location (UCSC) Chr 1: 171.25 – 171.29 Mb Chr 1: 162.66 – 162.69 Mb PubMed search [3] [4]
Wikidata
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Dimethylaniline monooxygenase [N-oxide-forming] 1 is an enzyme that in humans is encoded by the FMO1 gene.^[5]

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in humans resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in xenobiotics such as pesticides and drugs.^[5]