Clinical data | |
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Trade names | Ancobon, Ancotil, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a601132 |
Pregnancy category |
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Routes of administration | By mouth, intravenous |
ATC code | |
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Legal status | |
Pharmacokinetic data | |
Bioavailability | 75 to 90% (by mouth) |
Protein binding | 2.9 to 4% |
Metabolism | minimal, in the GI tract |
Elimination half-life | 2.4 to 4.8 hours |
Excretion | kidney (90%) |
Identifiers | |
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CAS Number | |
PubChem CID | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.016.336 |
Chemical and physical data | |
Formula | C4H4FN3O |
Molar mass | 129.094 g·mol−1 |
3D model (JSmol) | |
Melting point | 295 to 297 °C (563 to 567 °F) (dec.) |
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Flucytosine, also known as 5-fluorocytosine (5-FC), is an antifungal medication.[2] It is specifically used, together with amphotericin B, for serious Candida infections and cryptococcosis.[2] It may be used by itself or with other antifungals for chromomycosis.[2] Flucytosine is used by mouth and by injection into a vein.[2][3]
Common side effects include bone marrow suppression, loss of appetite, diarrhea, vomiting, and psychosis.[2] Anaphylaxis and other allergic reactions occasionally occur.[2] It is unclear if use in pregnancy is safe for the baby.[4] Flucytosine is in the fluorinated pyrimidine analogue family of medications.[2] It works by being converted into fluorouracil inside the fungus, which impairs its ability to make protein.[2]
Flucytosine was first made in 1957.[5] It is on the World Health Organization's List of Essential Medicines.[6] As of 2016, in the United States the medication cost about US$2,000 per day while in the United Kingdom it is about US$22 per day.[7] It is not available in much of the developing world.[8]