Flumedroxone acetate

Flumedroxone acetate
Clinical data
Trade names	Demigran, Leomigran
Other names	WG-537; 6α-(Trifluoromethyl)-17α-acetoxyprogesterone; 6α-(Trifluoromethyl)-17α-acetoxypregn-4-ene-3,20-dione
Routes of; administration	By mouth
Drug class	Progestogen; Progestin; Progestogen ester
ATC code	N02CB01 (WHO) ;
Identifiers
	IUPAC name [(6S,8R,9S,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-3-oxo-6-(trifluoromethyl)-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate;
CAS Number	987-18-8;
PubChem CID	192154;
ChemSpider	166814;
UNII	S0S93EK936;
CompTox Dashboard (EPA)	DTXSID701024795 ;
ECHA InfoCard	100.012.343
Chemical and physical data
Formula	C24H31F3O4
Molar mass	440.503 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(=O)[C@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2C[C@@H](C4=CC(=O)CC[C@]34C)C(F)(F)F)C)OC(=O)C;
	InChI InChI=1S/C24H31F3O4/c1-13(28)23(31-14(2)29)10-7-18-16-12-20(24(25,26)27)19-11-15(30)5-8-21(19,3)17(16)6-9-22(18,23)4/h11,16-18,20H,5-10,12H2,1-4H3/t16-,17+,18+,20+,21-,22+,23+/m1/s1; Key:MXZYUFNILISKBC-WXLIAARGSA-N;

Flumedroxone acetate, sold under the brand names Demigran and Leomigran, is a progestin medication which is or has been used as an antimigraine agent.^[2]^[3]^[4] It is taken by mouth.^[1]

^ ^a ^b Cite error: The named reference Heyck1981 was invoked but never defined (see the help page).
^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 560–. ISBN 978-1-4757-2085-3.
^ Bégué JP, Bonnet-Delpon D (2 June 2008). "Drugs for Endocrine and Metabolic Disorders". Bioorganic and Medicinal Chemistry of Fluorine. John Wiley & Sons. pp. 329–. ISBN 978-0-470-28187-1.
^ Hudgson P, Foster JB, Newell DJ (April 1967). "Controlled trial of demigran in the prophylaxis of migraine". British Medical Journal. 2 (5544): 91–93. doi:10.1136/bmj.2.5544.91. PMC 1841258. PMID 6020856.

[Heyck1981-1] Cite error: The named reference Heyck1981 was invoked but never defined (see the help page).

[Elks2014-2] Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 560–. ISBN 978-1-4757-2085-3.

[BéguéBonnet-Delpon2008-3] Bégué JP, Bonnet-Delpon D (2 June 2008). "Drugs for Endocrine and Metabolic Disorders". Bioorganic and Medicinal Chemistry of Fluorine. John Wiley & Sons. pp. 329–. ISBN 978-0-470-28187-1.

[pmid6020856-4] Hudgson P, Foster JB, Newell DJ (April 1967). "Controlled trial of demigran in the prophylaxis of migraine". British Medical Journal. 2 (5544): 91–93. doi:10.1136/bmj.2.5544.91. PMC 1841258. PMID 6020856.

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