Fomepizole

Fomepizole
Skeletal formula of fomepizole
Ball-and-stick model of the fomepizole molecule
Chemical structure of fomepizole
Clinical data
Pronunciation/ˌfˈmɛpɪzl/
Trade namesAntizol, others
Other names4-Methylpyrazole
AHFS/Drugs.comMonograph
License data
Routes of
administration
Intravenous
ATC code
Legal status
Legal status
Identifiers
  • 4-Methyl-1H-pyrazole
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.028.587 Edit this at Wikidata
Chemical and physical data
FormulaC4H6N2
Molar mass82.106 g·mol−1
3D model (JSmol)
Density0.99 g/cm3
Boiling point204 to 207 °C (399 to 405 °F) (at 97,3 kPa)
  • CC1=CNN=C1
  • InChI=1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6) checkY
  • Key:RIKMMFOAQPJVMX-UHFFFAOYSA-N

Fomepizole, also known as 4-methylpyrazole, is a medication used to treat methanol and ethylene glycol poisoning.[4] It may be used alone or together with hemodialysis.[4] It is given by injection into a vein.[4]

Common side effects include headache, nausea, sleepiness, and unsteadiness.[4] It is unclear if use during pregnancy causes risk to a fetus.[4] Fomepizole works by blocking the enzyme that converts methanol and ethylene glycol to their toxic breakdown products.[4]

Fomepizole was approved for medical use in the United States in 1997.[4] It is on the World Health Organization's List of Essential Medicines.[5]

  1. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
  2. ^ "Prescription medicines: registration of new chemical entities in Australia, 2016". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 10 April 2023.
  3. ^ "Antizol- fomepizole injection". DailyMed. U.S. National Library of Medicine. Retrieved 24 December 2020.
  4. ^ a b c d e f g "Fomepizole". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.
  5. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.