Foscarnet

Foscarnet
Clinical data
Trade namesFoscavir, Vocarvi, others
Other namesphosphonomethanoic acid, dihydroxyphosphinecarboxylic acid oxide
AHFS/Drugs.comMonograph
MedlinePlusa601144
License data
Pregnancy
category
  • AU: B3
Routes of
administration
Intravenous
ATC code
Legal status
Legal status
Pharmacokinetic data
BioavailabilityNA
Protein binding14–17%
Elimination half-life3.3–6.8 hours
Identifiers
  • phosphonoformic acid
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaCH3O5P
Molar mass126.004 g·mol−1
3D model (JSmol)
  • O=C(O)P(=O)(O)O
  • InChI=1S/CH3O5P/c2-1(3)7(4,5)6/h(H,2,3)(H2,4,5,6) checkY
  • Key:ZJAOAACCNHFJAH-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Foscarnet (phosphonomethanoic acid), known by its brand name Foscavir, is an antiviral medication which is primarily used to treat viral infections involving the Herpesviridae family. It is classified as a pyrophosphate analog DNA polymerase inhibitor.[3][4] Foscarnet is the conjugate base of a chemical compound with the formula HO2CPO3H2 (Trisodium phosphonoformate).[5][6]

Foscarnet was approved for medical use in 1991.[7] It is available as a generic medication.[8]

  1. ^ "Regulatory Decision Summary - Vocarvi". Health Canada. 23 October 2014. Retrieved 4 June 2022.
  2. ^ "Foscavir- foscarnet sodium injection, solution". DailyMed. 23 April 2020. Retrieved 6 November 2020.
  3. ^ Wagstaff AJ, Bryson HM (August 1994). "Foscarnet. A reappraisal of its antiviral activity, pharmacokinetic properties and therapeutic use in immunocompromised patients with viral infections". Drugs. 48 (2): 199–226. doi:10.2165/00003495-199448020-00007. PMID 7527325. S2CID 260483894.
  4. ^ Chrisp P, Clissold SP (January 1991). "Foscarnet. A review of its antiviral activity, pharmacokinetic properties and therapeutic use in immunocompromised patients with cytomegalovirus retinitis". Drugs. 41 (1): 104–129. doi:10.2165/00003495-199141010-00009. PMID 1706982.
  5. ^ Garikapati S, Nguyen M (2022). "Foscarnet". StatPearls. Treasure Island (FL): StatPearls Publishing. PMID 32310568. Retrieved 2022-04-04.
  6. ^ "phosphonoformic acid (CHEBI:127780)". www.ebi.ac.uk. Retrieved 2022-04-04.
  7. ^ Long SS, Pickering LK, Prober CG (2012). Principles and Practice of Pediatric Infectious Disease. Elsevier Health Sciences. p. 1502. ISBN 978-1437727029.
  8. ^ "Competitive Generic Therapy Approvals". U.S. Food and Drug Administration (FDA). 29 June 2023. Archived from the original on 29 June 2023. Retrieved 29 June 2023.