Francesco II Gonzaga | |
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| Born | 10 August 1466 Mantua, Margravate of Mantua |
| Died | 29 March 1519 (aged 52) Mantua, Margravate of Mantua |
| Noble family | House of Gonzaga |
| Spouse(s) | Isabella d'Este |
| Issue | Eleonor Gonzaga Ippolita Gonzaga Federico II, Duke of Mantua Ercole Gonzaga Ferrante Gonzaga |
| Father | Federico I Gonzaga |
| Mother | Margaret of Bavaria |
Francesco II Gonzaga (10 August 1466 – 29 March 1519) was the ruler of the Italian city of Mantua from 1484 until his death.