Francis Cabot Lowell may refer to:
- Francis Cabot Lowell (1775–1817), businessman and co-founder of Lowell, Massachusetts
- Francis Cabot Lowell, Jr. (1803–1874), industrialist (his son)
- Francis Cabot Lowell (judge) (1855–1911), United States federal judge and Massachusetts politician (his grandson)
- Francis Cabot Lowell, Jr. (1803–1874), industrialist (his son)
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