Francis Seymour may refer to:
- Francis Seymour, 1st Baron Seymour of Trowbridge (c. 1590–1664)
- Francis Seymour, 5th Duke of Somerset (1658–1678)
- Francis Seymour, of Sherborne, Dorset (1697–1761), Member of Parliament
- Francis Seymour, 5th Marquess of Hertford (1812–1884)
- Sir Francis Seymour, 1st Baronet (1813–1890), British Army officer and courtier
- Lord Francis Seymour (1725–1799), clergyman of the Church of England
- Frank Seymour (1904–1987), Australian rules footballer