Francis Talbot, 5th Earl of Shrewsbury, 5th Earl of Waterford, 11th Baron Talbot, KG (1500 – 25 September 1560) was the son of George Talbot, 4th Earl of Shrewsbury, and Anne Hastings. He also held the subsidiary titles of 14th Baron Strange of Blackmere and 10th Baron Furnivall.