Frank Guthrie

Frank Guthrie may refer to:

• Frank Guthrie (politician) (1893–1955), Australian politician
• Frank Guthrie (rugby union) (1869–1954), South African rugby player
• Frank Edwin Guthrie (1923-1994), entomologist, recipient of the 1983 North Carolina Award for Science
• Frank Guthrie (swimming coach), member of the International Swimming Hall of Fame