Frankel is a surname. Notable people with the surname include:
- Benjamin Frankel (1906–1973), British composer
- Bethenny Frankel (born 1970), American chef and reality television personality
- Charles Frankel (1917–1975), American philosopher, known for Charles Frankel Prize
- Cyril Frankel (1921–2017), British director
- Dan Frankel (American politician) (born 1956), member of the Pennsylvania House of Representatives
- Dan Frankel (British politician) (1900–1988), MP for Mile End, 1935–1945
- Dave Frankel, American attorney, former television weatherman and news anchor
- David Frankel (born 1959), American director, editor, screenwriter, executive producer
- Felice Frankel, American photographer of scientific art images, or artistic science images.
- Gene Frankel (1919–2005), American theater director
- Jacob Frankel (1808–1887), German-born American rabbi
- Jeffrey Frankel (born 1952), American economist
- Jerry Frankel (1930–2018), American musical theatre producer and thoroughbred breeder and owner
- Jonah Frankel (1928–2012), author, Hebrew literature professor and Israel Prize laureate
- Jonah Frankel (businessman) (died 1846), German Jewish businessman, banker and philanthropist
- Jonah Teomim-Frankel (1595–1669), author of the book Kikayon deYona
- Joseph Frankel (musician) (1882–1956), American army band and klezmer bandleader
- Justin Frankel (born 1978), American computer programmer
- Lee K. Frankel (1867–1931), American social worker and insurance executive
- Leó Frankel (1844–1896), Hungarian politician
- Lois Frankel (born 1948), member of the United States House of Representatives from Florida
- Martin Frankel (born 1954), American financier
- Max Frankel (born 1930), American journalist and former New York Times executive editor
- Naomi Frankel (1918–2009), German-Israeli novelist
- Otto Frankel (Otto Herzberg Frankel; 1900–1998), Australian biologist and geneticist of Austrian descent
- Richard B. Frankel, American physicist
- Robert "Bobby" J. Frankel (1941–2009), American thoroughbred race horse trainer
- Sandra Frankel (born 1941), former supervisor of the Town of Brighton, Monroe County, New York
- Susannah Frankel, British fashion journalist and author
- Susy Frankel, New Zealand law academic
- Stan Frankel (1919–1978), American physicist
- Theodore Frankel (1929–2017), American mathematician
- Tomer Frankel (born 2000), Israeli swimmer, European 2018 junior champion in the 100 m freestyle
- William Frankel (1903–2008), editor of the British weekly newspaper, The Jewish Chronicle, from 1958 to 1977
- Zecharias Frankel (1801–1875), Bohemian-German Conservative rabbi, historian