Frederick Lee may refer to:
- Frederick Lee, Baron Lee of Newton (1906–1984), British politician
- Frederick Lee (cricketer, born 1856) (1856–1896), English cricketer
- Frederick Lee (cricketer, born 1840) (1840–1922), English barrister and cricketer
- Fred Lee (cricketer, born 1871) (1871–1914), English cricketer
- Fred Lee (cricketer, born 1905) (1905–1977), English cricketer
- Frederick Lee (priest) (1832–1902), Church of England priest and author
- Frederick Richard Lee (1798–1879), English painter
- Frederic Sterling Lee (1949–2014), American economist
- Frederic Schiller Lee (1859–1939), American physiologist