| Frizzled/Smoothened family membrane region | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Crystal structure of the cysteine-rich domain of mouse frizzled 8 (mfz8)[1] | |||||||||
| Identifiers | |||||||||
| Symbol | Frizzled | ||||||||
| Pfam | PF01534 | ||||||||
| Pfam clan | GPCR_A | ||||||||
| InterPro | IPR000539 | ||||||||
| PROSITE | PDOC50038 | ||||||||
| TCDB | 9.A.14 | ||||||||
| OPM superfamily | 6 | ||||||||
| OPM protein | 4jkv | ||||||||
| CDD | cd13951 | ||||||||
| |||||||||
Frizzled is a family of atypical G protein-coupled receptors that serve as receptors in the Wnt signaling pathway and other signaling pathways.[2] When activated, Frizzled leads to activation of Dishevelled in the cytosol.
- ^ PDB: 1IJY; Dann CE, Hsieh JC, Rattner A, Sharma D, Nathans J, Leahy DJ (July 2001). "Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains". Nature. 412 (6842): 86–90. Bibcode:2001Natur.412...86D. doi:10.1038/35083601. PMID 11452312. S2CID 4303237.
- ^ Malbon CC (2004). "Frizzleds: new members of the superfamily of G-protein-coupled receptors". Front. Biosci. 9 (1–3): 1048–58. doi:10.2741/1308. PMID 14977528.