Fructose-bisphosphate aldolase

Fructose-bisphosphate aldolase
Fructose-bisphosphate aldolase octamer, Human
Identifiers
EC no.4.1.2.13
CAS no.9024-52-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
Fructose-bisphosphate aldolase class-I
fructose 1,6-bisphosphate aldolase from rabbit liver
Identifiers
SymbolGlycolytic
PfamPF00274
InterProIPR000741
PROSITEPDOC00143
SCOP21ald / SCOPe / SUPFAM
CDDcd00344
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
Fructose-bisphosphate aldolase class-II
class II fructose-1,6-bisphosphate aldolase in complex with phosphoglycolohydroxamate
Identifiers
SymbolF_bP_aldolase
PfamPF01116
Pfam clanCL0036
InterProIPR000771
PROSITEPDOC00523
SCOP21dos / SCOPe / SUPFAM
CDDcd00453
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Fructose-bisphosphate aldolase (EC 4.1.2.13), often just aldolase, is an enzyme catalyzing a reversible reaction that splits the aldol, fructose 1,6-bisphosphate, into the triose phosphates dihydroxyacetone phosphate (DHAP) and glyceraldehyde 3-phosphate (G3P). Aldolase can also produce DHAP from other (3S,4R)-ketose 1-phosphates such as fructose 1-phosphate and sedoheptulose 1,7-bisphosphate. Gluconeogenesis and the Calvin cycle, which are anabolic pathways, use the reverse reaction. Glycolysis, a catabolic pathway, uses the forward reaction. Aldolase is divided into two classes by mechanism.

The word aldolase also refers, more generally, to an enzyme that performs an aldol reaction (creating an aldol) or its reverse (cleaving an aldol), such as Sialic acid aldolase, which forms sialic acid. See the list of aldolases.