Fructose 1-phosphate

Fructose 1-phosphate
Names
IUPAC name
Fructose 1-(dihydrogen phosphate)
Systematic IUPAC name
(3S,4R,5R)-3,4,5,6-Tetrahydroxy-2-oxohexyl dihydrogen phosphate
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.036.451 Edit this at Wikidata
MeSH Fructose-1-phosphate
  • InChI=1S/C6H13O9P/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14/h3,5-8,10-11H,1-2H2,(H2,12,13,14)/t3-,5-,6-/m1/s1 checkY
    Key: ZKLLSNQJRLJIGT-UYFOZJQFSA-N checkY
  • InChI=1/C6H13O9P/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14/h3,5-8,10-11H,1-2H2,(H2,12,13,14)/t3-,5-,6-/m1/s1
    Key: ZKLLSNQJRLJIGT-UYFOZJQFBV
  • O=P(O)(O)OCC(=O)[C@@H](O)[C@H](O)[C@H](O)CO
Properties
C6H13O9P
Molar mass 260.136
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Fructose-1-phosphate is a derivative of fructose. It is generated mainly by hepatic fructokinase but is also generated in smaller amounts in the small intestinal mucosa and proximal epithelium of the renal tubule.[1] It is an important intermediate of glucose metabolism. Because fructokinase has a high Vmax fructose entering cells is quickly phosphorylated to fructose 1-phosphate.[1] In this form it is usually accumulated in the liver until it undergoes further conversion by aldolase B (the rate limiting enzyme of fructose metabolism).

Aldolase B converts it into glyceraldehyde and dihydroxyacetone phosphate (DHAP). Glyceraldehyde is then phosphorylated by triose kinase to glyceraldehyde 3-phosphate. Metabolism of fructose thus essentially results in intermediates of glycolysis. This means that fructose has the same fate as glucose after it gets metabolised. The final product of glycolysis (pyruvate) may then undergo gluconeogenesis, enter the TCA cycle or be stored as fatty acids.

  1. ^ a b "Marks A. Basic Medical Biochemistry: a clinical approach, 3rd ed. p.540