Fusidic acid

Fusidic acid
Clinical data
Trade names	Fucidin, Foban, others
Other names	Sodium fusidate
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of; administration	Topical
ATC code	D06AX01 (WHO) D09AA02 (WHO) (dressing) J01XC01 (WHO) S01AA13 (WHO);
Legal status
Legal status	NZ: Prescription only; UK: POM (Prescription only); US: OTC / Not approved; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	91% oral bioavailability
Protein binding	97 to 99%
Elimination half-life	Approximately 5 to 6 hours in adults
Identifiers
	IUPAC name 2-[(1S,2S,5R,6S,7S,10S,11S,13S,14Z,15R,17R)-13-(acetyloxy)-5,17-dihydroxy-2,6,10,11-tetramethyltetracyclo[8.7.0.02,7.011,15]heptadecan-14-ylidene]-6-methylhept-5-enoic acid;
CAS Number	6990-06-3 ;
PubChem CID	3000226;
DrugBank	DB02703 ;
ChemSpider	2271900 ;
UNII	59XE10C19C; J7P3696BCQ;
KEGG	D04281 ; D00213;
ChEBI	CHEBI:29013 ;
ChEMBL	ChEMBL374975 ;
PDB ligand	FUA (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID0023086 ;
ECHA InfoCard	100.027.506
Chemical and physical data
Formula	C31H48O6
Molar mass	516.719 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)/C(=C3/[C@@H]2C[C@@H](O)[C@H]1[C@@]4(C)CC[C@@H](O)[C@@H](C)[C@@H]4CC[C@@]1([C@]2(C[C@@H]3OC(=O)C)C)C)CC\C=C(/C)C;
	InChI InChI=1S/C31H48O6/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36)/b26-20-/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-/m0/s1 ; Key:IECPWNUMDGFDKC-MZJAQBGESA-N ;
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Fusidic acid, sold under the brand name Fucidin among others, is a steroid antibiotic that is often used topically in creams or ointments and eyedrops but may also be given systemically as tablets or injections. As of October 2008^[update], the global problem of advancing antimicrobial resistance has led to a renewed interest in its use.^[3]

^ "About fusidic acid". NHS. London. 30 November 2021. Retrieved 7 May 2024.
^ "Fucidin- sodium fusidate ointment". DailyMed. 6 November 2019. Retrieved 5 May 2024.
^ Falagas ME, Grammatikos AP, Michalopoulos A (October 2008). "Potential of old-generation antibiotics to address current need for new antibiotics". Expert Review of Anti-Infective Therapy. 6 (5): 593–600. doi:10.1586/14787210.6.5.593. PMID 18847400. S2CID 13158593.