G2-M DNA damage checkpoint

Steps of the cell cycle. The G2-M checkpoint occurs between the G2 and M phases.
G2-M arrest

The G2-M DNA damage checkpoint is an important cell cycle checkpoint in eukaryotic organisms that ensures that cells don't initiate mitosis until damaged or incompletely replicated DNA is sufficiently repaired. Cells with a defective G2-M checkpoint will undergo apoptosis or death after cell division if they enter the M phase before repairing their DNA.[1] The defining biochemical feature of this checkpoint is the activation of M-phase cyclin-CDK complexes, which phosphorylate proteins that promote spindle assembly and bring the cell to metaphase.[2]

  1. ^ Cuddihy, Andrew R.; O'Connell, Matthew J. (2003). Cell-cycle responses to DNA damage in G2. International Review of Cytology. Vol. 222. pp. 99–140. doi:10.1016/s0074-7696(02)22013-6. ISBN 9780123646262. ISSN 0074-7696. PMID 12503848.
  2. ^ Morgan, David Owen (2007). The cell cycle : principles of control. London: New Science Press. ISBN 978-0-19-920610-0. OCLC 70173205.