GAB2

GAB2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2VWF, 2W0Z, 5EXA, 5EWZ
Identifiers
Aliases	GAB2, entrez:9846, GRB2 associated binding protein 2
External IDs	OMIM: 606203; MGI: 1333854; HomoloGene: 69067; GeneCards: GAB2; OMA:GAB2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	78,418,348 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	96,958,153 bp
RNA expression pattern
	Top expressed in
	inferior ganglion of vagus nerve; ; subthalamic nucleus; ; medulla oblongata; ; superior vestibular nucleus; ; corpus callosum; ; external globus pallidus; ; ventral tegmental area; ; spinal cord; ; C1 segment; ; pars compacta;
	Top expressed in
	ascending aorta; ; aortic valve; ; retinal pigment epithelium; ; substantia nigra; ; decidua; ; ciliary body; ; renal corpuscle; ; facial motor nucleus; ; stroma of bone marrow; ; sexually immature organism;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatidylinositol-3,4,5-trisphosphate binding; transmembrane receptor protein tyrosine kinase adaptor activity; phosphatidylinositol-3,4-bisphosphate binding; protein binding; 1-phosphatidylinositol-3-kinase activity;
Cellular component	cytosol; plasma membrane; membrane; cytoplasm;
Biological process	positive regulation of mast cell degranulation; osteoclast differentiation; phosphatidylinositol-mediated signaling; positive regulation of cell population proliferation; Fc-epsilon receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; axon guidance; cytokine-mediated signaling pathway; phosphatidylinositol-3-phosphate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	9846
	14389
	ENSG00000033327
	ENSMUSG00000004508
	Q9UQC2
	Q9Z1S8
	NM_012296; NM_080491
	NM_001162477; NM_010248
	NP_036428; NP_536739
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

GRB2-associated-binding protein 2 also known as GAB2 is a protein that in humans is encoded by the GAB2 gene.^[5]^[6]^[7]^[8]

GAB2 is a docking protein with a conserved, folded PH domain attached to the membrane and a large disordered region, which hosts interactions with signaling molecules. It is a member of the GAB/DOS family localized on the internal membrane of the cell. It mediates the interaction between receptor tyrosine kinases (RTKs) and non-RTK receptors serving as the gateway into the cell for activation of SHP2, Phosphatidylinositol 3-kinase (PI3K), Grb2, ERK, and AKT and acting as one of the first steps in these signaling pathways. GAB2 has been shown to be important in physiological functions such as growth in bone marrow and cardiac function. GAB2 has also been associated with many diseases including leukemia and Alzheimer's disease.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000033327 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004508 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gu H, Pratt JC, Burakoff SJ, Neel BG (December 1998). "Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation". Molecular Cell. 2 (6): 729–40. doi:10.1016/s1097-2765(00)80288-9. PMID 9885561.
^ Zhao C, Yu DH, Shen R, Feng GS (July 1999). "Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1". The Journal of Biological Chemistry. 274 (28): 19649–54. doi:10.1074/jbc.274.28.19649. PMID 10391903.
^ Nishida K, Yoshida Y, Itoh M, Fukada T, Ohtani T, Shirogane T, Atsumi T, Takahashi-Tezuka M, Ishihara K, Hibi M, Hirano T (March 1999). "Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors". Blood. 93 (6): 1809–16. doi:10.1182/blood.V93.6.1809.406k35_1809_1816. PMID 10068651.
^ "Entrez Gene: GAB2 GRB2-associated binding protein 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000033327 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004508 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[:0-5] Gu H, Pratt JC, Burakoff SJ, Neel BG (December 1998). "Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation". Molecular Cell. 2 (6): 729–40. doi:10.1016/s1097-2765(00)80288-9. PMID 9885561.

[pmid10391903-6] Zhao C, Yu DH, Shen R, Feng GS (July 1999). "Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1". The Journal of Biological Chemistry. 274 (28): 19649–54. doi:10.1074/jbc.274.28.19649. PMID 10391903.

[pmid10068651-7] Nishida K, Yoshida Y, Itoh M, Fukada T, Ohtani T, Shirogane T, Atsumi T, Takahashi-Tezuka M, Ishihara K, Hibi M, Hirano T (March 1999). "Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors". Blood. 93 (6): 1809–16. doi:10.1182/blood.V93.6.1809.406k35_1809_1816. PMID 10068651.

[entrez-8] "Entrez Gene: GAB2 GRB2-associated binding protein 2".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]