GABA transporters (gamma-aminobutyric acid transporters) are a family of neurotransmitter / sodium symporters, belonging to the solute carrier 6 (SLC6) family.[1][2] They are found in various regions of the brain in different cell types, such as neurons and astrocytes.
These transporters are primarily responsible for the regulation of extracellular GABA concentration during basal and synaptic activity. They are responsible for creating a GABA gradient which is determined by the membrane potential, and the concentration of Na+ and Cl−. They are also present on the plasma membrane of neurons and glia which help define their function of regulation of GABA concentration as they act as the receptors that facilitate recycling of GABA in the extracellular space.[1] GABA transporters are a common target for anticonvulsant drugs against seizure disorders such as epilepsy.[3]