GABRA5

GABRA5
Identifiers
Aliases	GABRA5, gamma-aminobutyric acid type A receptor alpha5 subunit, EIEE79, gamma-aminobutyric acid type A receptor subunit alpha5, DEE79
External IDs	OMIM: 137142; MGI: 95617; HomoloGene: 20219; GeneCards: GABRA5; OMA:GABRA5 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	26,949,208 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	57,159,807 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; prefrontal cortex; ; Brodmann area 10; ; cingulate gyrus; ; anterior cingulate cortex; ; orbitofrontal cortex; ; dorsolateral prefrontal cortex; ; hippocampus proper; ; Region I of hippocampus proper; ; Brodmann area 9;
	Top expressed in
	subdivision of hippocampus; ; Region I of hippocampus proper; ; hippocampus proper; ; Subplate; ; dentate gyrus; ; dentate gyrus of hippocampal formation granule cell; ; ventromedial nucleus; ; lumbar subsegment of spinal cord; ; subiculum; ; arcuate nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	GABA-A receptor activity; transporter activity; ion channel activity; chloride channel activity; extracellular ligand-gated ion channel activity; transmembrane signaling receptor activity; signaling receptor activity; GABA receptor binding; inhibitory extracellular ligand-gated ion channel activity; benzodiazepine receptor activity; GABA-gated chloride ion channel activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	integral component of membrane; cell body; GABA-A receptor complex; postsynaptic membrane; membrane; receptor complex; synapse; integral component of plasma membrane; chloride channel complex; neuronal cell body membrane; dendrite; nucleoplasm; cytosol; plasma membrane; cell junction; GABA-ergic synapse; integral component of postsynaptic membrane; integral component of presynaptic membrane; integral component of postsynaptic specialization membrane; dendrite membrane; neuron projection; postsynapse;
Biological process	gamma-aminobutyric acid signaling pathway; negative regulation of neuron apoptotic process; cochlea development; associative learning; regulation of neuron apoptotic process; neuron development; chloride transmembrane transport; hearing; ion transport; behavioral fear response; brain development; inner ear receptor cell development; chloride transport; innervation; signal transduction; chemical synaptic transmission; ion transmembrane transport; regulation of membrane potential; nervous system process; synaptic transmission, GABAergic; regulation of postsynaptic membrane potential;
	Sources:Amigo / QuickGO
Orthologs
	2558
	110886
	ENSG00000186297
	ENSMUSG00000055078
	P31644
	Q8BHJ7
	NM_000810; NM_001165037
	NM_176942; NM_001362161; NM_001362162
	NP_000801; NP_001158509
	NP_795916; NP_001349090; NP_001349091
	Wikidata
View/Edit Human	View/Edit Mouse

Gamma-aminobutyric acid (GABA) A receptor, alpha 5, also known as GABRA5, is a protein which in humans is encoded by the GABRA5 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186297 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000055078 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5".
^ Wingrove P, Hadingham K, Wafford K, Kemp JA, Ragan CI, Whiting P (February 1992). "Cloning and expression of a cDNA encoding the human GABA-A receptor alpha 5 subunit". Biochem. Soc. Trans. 20 (1): 18S. doi:10.1042/bst020018s. PMID 1321750.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186297 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055078 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5".

[pmid1321750-6] Wingrove P, Hadingham K, Wafford K, Kemp JA, Ragan CI, Whiting P (February 1992). "Cloning and expression of a cDNA encoding the human GABA-A receptor alpha 5 subunit". Biochem. Soc. Trans. 20 (1): 18S. doi:10.1042/bst020018s. PMID 1321750.

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