GAL3ST3

GAL3ST3
Identifiers
Aliases	GAL3ST3, GAL3ST-3, GAL3ST2, galactose-3-O-sulfotransferase 3
External IDs	OMIM: 608234; MGI: 3617843; HomoloGene: 57198; GeneCards: GAL3ST3; OMA:GAL3ST3 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	66,049,161 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	5,358,766 bp
RNA expression pattern
	Top expressed in
	gonad; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; caudate nucleus; ; putamen; ; right auricle; ; nucleus accumbens; ; right hemisphere of cerebellum; ; right frontal lobe; ; prefrontal cortex;
	Top expressed in
	hippocampus proper; ; primary visual cortex; ; striatum of neuraxis; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; cerebellum; ; cerebellar cortex; ; neural tube; ; mesencephalon; ; olfactory bulb;
	More reference expression data
	n/a
Gene ontology
Molecular function	galactose 3-O-sulfotransferase activity; transferase activity; galactosylceramide sulfotransferase activity; proteoglycan sulfotransferase activity; 3'-phosphoadenosine 5'-phosphosulfate binding; carbohydrate binding;
Cellular component	integral component of membrane; Golgi cisterna membrane; Golgi apparatus; membrane;
Biological process	glycolipid biosynthetic process; sulfur compound metabolic process; poly-N-acetyllactosamine metabolic process; oligosaccharide metabolic process; proteoglycan biosynthetic process; monosaccharide metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	89792
	545276
	ENSG00000175229
	ENSMUSG00000047658
	Q96A11
	P61315
	NM_033036
	NM_001024717
	NP_149025
	NP_001019888
	Wikidata
View/Edit Human	View/Edit Mouse

Galactose-3-O-sulfotransferase 3 is an enzyme that in humans is encoded by the GAL3ST3 gene.^[5]^[6]^[7]

This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the 3' position of galactose in N-acetyllactosamine in both type 2 (Gal-beta-1-4GlcNAc-R) oligosaccharides and core-2-branched O-glycans, but not on type 1 or core-1-branched structures. This gene, which has also been referred to as GAL3ST2, is different from the GAL3ST2 gene located on chromosome 2 that encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 3.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175229 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047658 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Suzuki A, Hiraoka N, Suzuki M, Angata K, Misra AK, McAuliffe J, Hindsgaul O, Fukuda M (Jun 2001). "Molecular cloning and expression of a novel human beta-Gal-3-O-sulfotransferase that acts preferentially on N-acetyllactosamine in N- and O-glycans". J Biol Chem. 276 (26): 24388–95. doi:10.1074/jbc.M103135200. PMID 11323440.
^ El-Fasakhany FM, Uchimura K, Kannagi R, Muramatsu T (Jul 2001). "A novel human Gal-3-O-sulfotransferase: molecular cloning, characterization, and its implications in biosynthesis of (SO(4)-3)Galbeta1-4(Fucalpha1-3)GlcNAc". J Biol Chem. 276 (29): 26988–94. doi:10.1074/jbc.M100348200. PMID 11356829.
^ ^a ^b "Entrez Gene: GAL3ST3 galactose-3-O-sulfotransferase 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175229 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000047658 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11323440-5] Suzuki A, Hiraoka N, Suzuki M, Angata K, Misra AK, McAuliffe J, Hindsgaul O, Fukuda M (Jun 2001). "Molecular cloning and expression of a novel human beta-Gal-3-O-sulfotransferase that acts preferentially on N-acetyllactosamine in N- and O-glycans". J Biol Chem. 276 (26): 24388–95. doi:10.1074/jbc.M103135200. PMID 11323440.

[pmid11356829-6] El-Fasakhany FM, Uchimura K, Kannagi R, Muramatsu T (Jul 2001). "A novel human Gal-3-O-sulfotransferase: molecular cloning, characterization, and its implications in biosynthesis of (SO(4)-3)Galbeta1-4(Fucalpha1-3)GlcNAc". J Biol Chem. 276 (29): 26988–94. doi:10.1074/jbc.M100348200. PMID 11356829.

[entrez-7] "Entrez Gene: GAL3ST3 galactose-3-O-sulfotransferase 3".

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