GBGT1

GBGT1
Identifiers
Aliases	GBGT1, A3GALNT, FS, UNQ2513, globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group)
External IDs	OMIM: 606074; MGI: 2449143; HomoloGene: 110677; GeneCards: GBGT1; OMA:GBGT1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	133,163,933 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	28,395,427 bp
RNA expression pattern
	Top expressed in
	body of stomach; ; monocyte; ; blood; ; right ovary; ; left ovary; ; granulocyte; ; right adrenal gland; ; right adrenal cortex; ; apex of heart; ; left adrenal gland;
	Top expressed in
	embryo; ; embryo; ; blastocyst; ; muscle of thigh; ; esophagus; ; morula; ; spermatocyte; ; spermatid; ; lip; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; hexosyltransferase activity; metal ion binding; glycosyltransferase activity; globoside alpha-N-acetylgalactosaminyltransferase activity;
Cellular component	integral component of membrane; Golgi membrane; membrane; Golgi apparatus; vesicle;
Biological process	glycolipid biosynthetic process; protein glycosylation; lipid glycosylation; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	26301
	227671
	ENSG00000148288
	ENSMUSG00000026829
	Q8N5D6
	Q8VI38
	NM_021996; NM_001282629; NM_001282632; NM_001288572; NM_001288573
	NM_139197
	NP_001269558; NP_001269561; NP_001275501; NP_001275502; NP_068836
	NP_631936
	Wikidata
View/Edit Human	View/Edit Mouse

Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the GBGT1 gene.^[5]^[6]^[7]

This gene encodes a member of the histo-blood group ABO gene family that encodes glycosyltransferases with related but distinct substrate specificity. This protein plays a role in synthesizing Forssman glycolipid (FG), a member of the globoseries glycolipid family. Human cells do not normally produce FG but produce the precursor glycolipids globotriaosylceramide and globoside. This protein may be involved in the tropism and binding of pathogenic organisms.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000148288 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026829 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Xu H, Storch T, Yu M, Elliott SP, Haslam DB (October 1999). "Characterization of the human Forssman synthetase gene. An evolving association between glycolipid synthesis and host-microbial interactions". The Journal of Biological Chemistry. 274 (41): 29390–8. doi:10.1074/jbc.274.41.29390. PMID 10506200.
^ Haslam DB, Baenziger JU (October 1996). "Expression cloning of Forssman glycolipid synthetase: a novel member of the histo-blood group ABO gene family". Proceedings of the National Academy of Sciences of the United States of America. 93 (20): 10697–702. Bibcode:1996PNAS...9310697H. doi:10.1073/pnas.93.20.10697. PMC 38217. PMID 8855242.
^ ^a ^b "Entrez Gene: GBGT1 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148288 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026829 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10506200-5] Xu H, Storch T, Yu M, Elliott SP, Haslam DB (October 1999). "Characterization of the human Forssman synthetase gene. An evolving association between glycolipid synthesis and host-microbial interactions". The Journal of Biological Chemistry. 274 (41): 29390–8. doi:10.1074/jbc.274.41.29390. PMID 10506200.

[pmid8855242-6] Haslam DB, Baenziger JU (October 1996). "Expression cloning of Forssman glycolipid synthetase: a novel member of the histo-blood group ABO gene family". Proceedings of the National Academy of Sciences of the United States of America. 93 (20): 10697–702. Bibcode:1996PNAS...9310697H. doi:10.1073/pnas.93.20.10697. PMC 38217. PMID 8855242.

[entrez-7] "Entrez Gene: GBGT1 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1".

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