GDP-fucose protein O-fucosyltransferase 2

POFUT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4AP5, 4AP6
Identifiers
Aliases	POFUT2, C21orf80, FUT13, protein O-fucosyltransferase 2
External IDs	OMIM: 610249; MGI: 1916863; HomoloGene: 12724; GeneCards: POFUT2; OMA:POFUT2 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	45,287,898 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	77,105,409 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; stromal cell of endometrium; ; anterior pituitary; ; right lobe of thyroid gland; ; canal of the cervix; ; left lobe of thyroid gland; ; left ovary; ; sural nerve; ; pancreatic ductal cell; ; right ovary;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; fossa; ; condyle; ; vas deferens; ; Gonadal ridge; ; human fetus; ; molar; ; body of femur; ; umbilical cord;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; fucosyltransferase activity; glycosyltransferase activity; peptide-O-fucosyltransferase activity;
Cellular component	Golgi apparatus; endoplasmic reticulum; endoplasmic reticulum membrane;
Biological process	regulation of gene expression; fucose metabolic process; protein glycosylation; regulation of epithelial to mesenchymal transition; mesoderm formation; regulation of secretion; protein O-linked fucosylation; fucosylation; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	23275
	80294
	ENSG00000186866
	ENSMUSG00000020260
	Q9Y2G5
	Q8VHI3
	NM_015227; NM_133634; NM_133635
	NM_030262
	NP_056042; NP_598368
	NP_084538
	Wikidata
View/Edit Human	View/Edit Mouse

GDP-fucose protein O-fucosyltransferase 2 (POFUT2) is an enzyme responsible for adding fucose sugars in O linkage to serine or threonine residues in Thrombospondin repeats.^[5] The protein is an inverting glycosyltransferase, which means that the enzyme uses GDP-β-L-fucose as a donor substrate and transfers the fucose in O linkage to the protein producing fucose-α-O-serine/threonine.

Almost all glycosyltransferases reside in the Golgi apparatus. However, POFUT2 as well as the related enzyme POFUT1 have recently been shown to reside in the endoplasmic reticulum.

The malaria parasite Plasmodium falciparum requires POFUT2 for efficient transmission to mosquitoes and infection of human liver cells.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186866 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020260 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ GDP-fucose protein O-fucosyltransferase 2, The Universal Protein Resource
^ Lopaticki S, Yang AS, John A, Scott NE, Lingford JP, O'Neill MT, et al. (September 2017). "Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts". Nature Communications. 8 (1): 561. Bibcode:2017NatCo...8..561L. doi:10.1038/s41467-017-00571-y. PMC 5601480. PMID 28916755.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186866 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020260 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] GDP-fucose protein O-fucosyltransferase 2, The Universal Protein Resource

[6] Lopaticki S, Yang AS, John A, Scott NE, Lingford JP, O'Neill MT, et al. (September 2017). "Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts". Nature Communications. 8 (1): 561. Bibcode:2017NatCo...8..561L. doi:10.1038/s41467-017-00571-y. PMC 5601480. PMID 28916755.

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