GFM1

GFM1
Identifiers
Aliases	GFM1, COXPD1, EFG, EFG1, EFGM, EGF1, GFM, hEFG1, G elongation factor, mitochondrial 1, G elongation factor mitochondrial 1, mtEF-G1
External IDs	OMIM: 606639; MGI: 107339; HomoloGene: 6449; GeneCards: GFM1; OMA:GFM1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	158,692,575 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	67,383,862 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; biceps brachii; ; Brodmann area 23; ; Skeletal muscle tissue of biceps brachii; ; retinal pigment epithelium; ; Skeletal muscle tissue of rectus abdominis; ; right ventricle; ; germinal epithelium; ; mucosa of sigmoid colon; ; parietal pleura;
	Top expressed in
	myocardium of ventricle; ; otic placode; ; right kidney; ; cardiac muscles; ; cardiac muscle tissue of left ventricle; ; digastric muscle; ; masseter muscle; ; right ventricle; ; proximal tubule; ; temporal muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein binding; GTPase activity; translation elongation factor activity; RNA binding;
Cellular component	mitochondrial matrix; intracellular anatomical structure; mitochondrion;
Biological process	translational elongation; protein biosynthesis; mitochondrial translational elongation;
	Sources:Amigo / QuickGO
Orthologs
	85476
	28030
	ENSG00000168827
	ENSMUSG00000027774
	Q96RP9
	Q8K0D5
	NM_001308164; NM_001308166; NM_024996
	NM_138591
NP_001295093; NP_001295095; NP_079272; NP_001361284; NP_001361285;
	NP_001361286; NP_001361287; NP_001361288; NP_001361289; NP_001361290
	NP_613057
	Wikidata
View/Edit Human	View/Edit Mouse

Elongation factor G 1, mitochondrial is a protein that in humans is encoded by the GFM1 gene. It is an EF-G homolog.^[5]^[6]^[7]

Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168827 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027774 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gao J, Yu L, Zhang P, Jiang J, Chen J, Peng J, Wei Y, Zhao S (May 2001). "Cloning and characterization of human and mouse mitochondrial elongation factor G, GFM and Gfm, and mapping of GFM to human chromosome 3q25.1-q26.2". Genomics. 74 (1): 109–14. doi:10.1006/geno.2001.6536. PMID 11374907.
^ Hammarsund M, Wilson W, Corcoran M, Merup M, Einhorn S, Grander D, Sangfelt O (Dec 2001). "Identification and characterization of two novel human mitochondrial elongation factor genes, hEFG2 and hEFG1, phylogenetically conserved through evolution". Hum Genet. 109 (5): 542–50. doi:10.1007/s00439-001-0610-5. PMID 11735030. S2CID 24508386.
^ ^a ^b "Entrez Gene: GFM1 G elongation factor, mitochondrial 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168827 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027774 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11374907-5] Gao J, Yu L, Zhang P, Jiang J, Chen J, Peng J, Wei Y, Zhao S (May 2001). "Cloning and characterization of human and mouse mitochondrial elongation factor G, GFM and Gfm, and mapping of GFM to human chromosome 3q25.1-q26.2". Genomics. 74 (1): 109–14. doi:10.1006/geno.2001.6536. PMID 11374907.

[pmid11735030-6] Hammarsund M, Wilson W, Corcoran M, Merup M, Einhorn S, Grander D, Sangfelt O (Dec 2001). "Identification and characterization of two novel human mitochondrial elongation factor genes, hEFG2 and hEFG1, phylogenetically conserved through evolution". Hum Genet. 109 (5): 542–50. doi:10.1007/s00439-001-0610-5. PMID 11735030. S2CID 24508386.

[entrez-7] "Entrez Gene: GFM1 G elongation factor, mitochondrial 1".

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