GLA (gene)

GLA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1R46, 1R47, 3GXN, 3GXP, 3GXT, 3HG2, 3HG3, 3HG4, 3HG5, 3LX9, 3LXA, 3LXB, 3LXC, 3S5Y, 3S5Z, 3TV8, 4NXS
Identifiers
Aliases	GLA, GALA, galactosidase alpha
External IDs	OMIM: 300644; MGI: 1347344; HomoloGene: 90852; GeneCards: GLA; OMA:GLA - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq22.1 Start 101,393,273 bp[1] End 101,408,012 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X E3|X 56.2 cM Start 133,488,898 bp[2] End 133,501,874 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell monocyte seminal vesicula amniotic fluid stromal cell of endometrium islet of Langerhans bone marrow blood granulocyte mucosa of transverse colon Top expressed in decidua granulocyte stroma of bone marrow morula lumbar spinal ganglion endothelial cell of lymphatic vessel calvaria blastocyst ileum blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hydrolase activity, hydrolyzing O-glycosyl compounds protein homodimerization activity hydrolase activity, acting on glycosyl bonds raffinose alpha-galactosidase activity protein binding galactoside binding catalytic activity signaling receptor binding hydrolase activity alpha-galactosidase activity Cellular component cytoplasm Golgi apparatus lysosomal lumen lysosome extracellular exosome extracellular region azurophil granule lumen Biological process negative regulation of nitric-oxide synthase activity glycosphingolipid metabolic process glycosphingolipid catabolic process negative regulation of nitric oxide biosynthetic process metabolism oligosaccharide metabolic process neutrophil degranulation glycoside catabolic process glycosylceramide catabolic process carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2717 11605 Ensembl ENSG00000102393 ENSMUSG00000031266 UniProt P06280 P51569 RefSeq (mRNA) NM_000169 NM_013463 RefSeq (protein) NP_000160 NP_038491 Location (UCSC) Chr X: 101.39 – 101.41 Mb Chr X: 133.49 – 133.5 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Galactosidase alpha is an enzyme that in humans is encoded by the GLA gene.^[5]

Two recombinant forms of human α-galactosidase are called agalsidase alpha (INN) and agalsidase beta (INN).^[6] A mold-derived form is the primary ingredient in gas relief supplements.^{[citation needed]}