GLUT1

glucose transporter, type 1
Identifiers
AliasesGlu_transpt_1IPR002439erythrocyte/brain hexose facilitatorGLUT1glucose transporter-1Gtr1Glut1Glut-1Glucose Transporter Type 1
External IDsGeneCards: [1]; OMA:- orthologs
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Glucose transporter 1 (or GLUT1), also known as solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), is a uniporter protein that in humans is encoded by the SLC2A1 gene.[1] GLUT1 facilitates the transport of glucose across the plasma membranes of mammalian cells.[2] This gene encodes a facilitative glucose transporter that is highly expressed in erythrocytes and endothelial cells, including cells of the blood–brain barrier. The encoded protein is found primarily in the cell membrane and on the cell surface, where it can also function as a receptor for human T-cell leukemia virus (HTLV) I and II.[3] GLUT1 accounts for 2 percent of the protein in the plasma membrane of erythrocytes.

Mutations in this gene can cause GLUT1 deficiency syndrome 1, GLUT1 deficiency syndrome 2, idiopathic generalized epilepsy 12, dystonia 9, and stomatin-deficient cryohydrocytosis.[4][5]

  1. ^ Mueckler M, Caruso C, Baldwin SA, Panico M, Blench I, Morris HR, Allard WJ, Lienhard GE, Lodish HF (September 1985). "Sequence and structure of a human glucose transporter". Science. 229 (4717): 941–5. Bibcode:1985Sci...229..941M. doi:10.1126/science.3839598. PMID 3839598.
  2. ^ Olson AL, Pessin JE (1996). "Structure, function, and regulation of the mammalian facilitative glucose transporter gene family". Annual Review of Nutrition. 16: 235–56. doi:10.1146/annurev.nu.16.070196.001315. PMID 8839927.
  3. ^ Public Domain This article incorporates text from this source, which is in the public domain: "Entrez Gene: Transmembrane protein 70". Retrieved 2018-08-14.
  4. ^ "SLC2A1 – Solute carrier family 2, facilitated glucose transporter member 1 – Homo sapiens (Human) – SLC2A1 gene & protein". www.uniprot.org. Retrieved 2018-08-27. This article incorporates text available under the CC BY 4.0 license.
  5. ^ "UniProt: the universal protein knowledgebase". Nucleic Acids Research. 45 (D1): D158–D169. January 2017. doi:10.1093/nar/gkw1099. PMC 5210571. PMID 27899622.