GNA12

GNA12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZCA
Identifiers
Aliases	GNA12, NNX3, RMP, gep, G protein subunit alpha 12, HG1M1
External IDs	OMIM: 604394; MGI: 95767; HomoloGene: 22398; GeneCards: GNA12; OMA:GNA12 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	2,844,308 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	140,816,186 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; stromal cell of endometrium; ; internal globus pallidus; ; C1 segment; ; amygdala; ; nucleus accumbens; ; putamen; ; caudate nucleus; ; substantia nigra; ; right coronary artery;
	Top expressed in
	right kidney; ; myocardium of ventricle; ; ventricular zone; ; interventricular septum; ; zygote; ; stroma of bone marrow; ; cardiac muscle tissue of left ventricle; ; molar; ; right ventricle; ; proximal tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; metal ion binding; protein binding; guanyl nucleotide binding; G protein-coupled receptor binding; D5 dopamine receptor binding; signal transducer activity; G-protein beta/gamma-subunit complex binding; GTPase activity;
Cellular component	membrane; focal adhesion; heterotrimeric G-protein complex; brush border membrane; cytoplasm; plasma membrane; lateral plasma membrane;
Biological process	cell differentiation; intracellular signal transduction; regulation of TOR signaling; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; small GTPase mediated signal transduction; embryonic digit morphogenesis; blood coagulation; in utero embryonic development; platelet activation; regulation of cell shape; regulation of proteasomal ubiquitin-dependent protein catabolic process; signal transduction; G protein-coupled receptor signaling pathway; regulation of fibroblast migration; Rho protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	2768
	14673
	ENSG00000146535
	ENSMUSG00000000149
	Q03113
	P27600
	NM_001282440; NM_001282441; NM_001293092; NM_007353
	NM_010302
	NP_001269369; NP_001269370; NP_001280021; NP_031379
	NP_034432
	Wikidata
View/Edit Human	View/Edit Mouse

Guanine nucleotide-binding protein subunit alpha-12 is a protein that in humans is encoded by the GNA12 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000146535 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000149 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA (February 1993). "Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product". Molecular and Cellular Biology. 13 (2): 762–8. doi:10.1128/mcb.13.2.762. PMC 358958. PMID 8423800.
^ Kumar RN, Shore SK, Dhanasekaran N (February 2006). "Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3". Oncogene. 25 (6): 899–906. doi:10.1038/sj.onc.1209132. PMID 16247467.
^ "Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000146535 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000149 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8423800-5] Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA (February 1993). "Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product". Molecular and Cellular Biology. 13 (2): 762–8. doi:10.1128/mcb.13.2.762. PMC 358958. PMID 8423800.

[pmid16247467-6] Kumar RN, Shore SK, Dhanasekaran N (February 2006). "Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3". Oncogene. 25 (6): 899–906. doi:10.1038/sj.onc.1209132. PMID 16247467.

[entrez-7] "Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12".

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