GNAI2

GNAI2
Identifiers
Aliases	GNAI2, GIP, GNAI2B, H_LUCA15.1, H_LUCA16.1, G protein subunit alpha i2, HG1C
External IDs	OMIM: 139360; MGI: 95772; HomoloGene: 55539; GeneCards: GNAI2; OMA:GNAI2 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	50,259,362 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	107,512,566 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; right lung; ; stromal cell of endometrium; ; C1 segment; ; right coronary artery; ; upper lobe of left lung; ; thoracic aorta; ; Descending thoracic aorta; ; ascending aorta;
	Top expressed in
	Ileal epithelium; ; granulocyte; ; external carotid artery; ; lactiferous gland; ; internal carotid artery; ; median eminence; ; entorhinal cortex; ; perirhinal cortex; ; choroid plexus of fourth ventricle; ; corneal stroma;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; G-protein beta/gamma-subunit complex binding; signal transducer activity; metal ion binding; protein binding; guanyl nucleotide binding; G protein-coupled receptor binding; GTP binding; GTPase activity;
Cellular component	cytoplasm; cell body; extracellular vesicle; centrosome; membrane; plasma membrane; nucleoplasm; microtubule organizing center; dendrite; midbody; heterotrimeric G-protein complex; membrane raft; extracellular exosome; cytoskeleton; nucleus; cytosol;
Biological process	gamma-aminobutyric acid signaling pathway; G protein-coupled acetylcholine receptor signaling pathway; G protein-coupled receptor signaling pathway; G protein-coupled adenosine receptor signaling pathway; negative regulation of adenylate cyclase activity; intracellular signal transduction; regulation of calcium ion transport; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; response to nutrient; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; negative regulation of synaptic transmission; cell division; positive regulation of cell population proliferation; cell cycle; cell population proliferation; signal transduction; protein folding; adenylate cyclase-activating G protein-coupled receptor signaling pathway; positive regulation of cell migration; positive regulation of superoxide anion generation; positive regulation of NAD(P)H oxidase activity; positive regulation of urine volume; positive regulation of renal sodium excretion; negative regulation of calcium ion-dependent exocytosis; positive regulation of insulin receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process; negative regulation of protein tyrosine phosphatase activity; positive regulation of vascular associated smooth muscle cell proliferation; positive regulation of neural precursor cell proliferation; negative regulation of apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2771
	14678
	ENSG00000114353
	ENSMUSG00000032562
	P04899
	P08752
NM_002070; NM_001166425; NM_001282617; NM_001282618; NM_001282619;
	NM_001282620
	NM_008138
NP_001159897; NP_001269546; NP_001269547; NP_001269548; NP_001269549;
	NP_002061
	NP_032164
	Wikidata
View/Edit Human	View/Edit Mouse

Guanine nucleotide-binding protein G(i), alpha-2 subunit is a protein that in humans is encoded by the GNAI2 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000114353 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032562 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Didsbury JR, Ho YS, Snyderman R (Jan 1987). "Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA". FEBS Letters. 211 (2): 160–4. doi:10.1016/0014-5793(87)81428-X. PMID 3100330. S2CID 84535945.
^ Magovcevic I, Ang SL, Seidman JG, Tolman CJ, Neer EJ, Morton CC (Jan 1992). "Regional localization of the human G protein alpha i2 (GNAI2) gene: assignment to 3p21 and a related sequence (GNAI2L) to 12p12-p13". Genomics. 12 (1): 125–9. doi:10.1016/0888-7543(92)90414-N. PMID 1733849.
^ "Entrez Gene: GNAI2 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000114353 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032562 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3100330-5] Didsbury JR, Ho YS, Snyderman R (Jan 1987). "Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA". FEBS Letters. 211 (2): 160–4. doi:10.1016/0014-5793(87)81428-X. PMID 3100330. S2CID 84535945.

[pmid1733849-6] Magovcevic I, Ang SL, Seidman JG, Tolman CJ, Neer EJ, Morton CC (Jan 1992). "Regional localization of the human G protein alpha i2 (GNAI2) gene: assignment to 3p21 and a related sequence (GNAI2L) to 12p12-p13". Genomics. 12 (1): 125–9. doi:10.1016/0888-7543(92)90414-N. PMID 1733849.

[7] "Entrez Gene: GNAI2 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2".

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