GNAI3

GNAI3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IHB, 2ODE, 2V4Z, 4G5O, 4G5R, 4G5S
Identifiers
Aliases	GNAI3, 87U6, ARCND1, G protein subunit alpha i3, HG1A
External IDs	OMIM: 139370; MGI: 95773; HomoloGene: 55975; GeneCards: GNAI3; OMA:GNAI3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	109,600,195 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	108,053,462 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; skin of thigh; ; parietal pleura; ; visceral pleura; ; hair follicle; ; skin of hip; ; tibia; ; cartilage tissue; ; oral cavity; ; cervix epithelium;
	Top expressed in
	abdominal wall; ; medial ganglionic eminence; ; dermis; ; skin of external ear; ; primitive streak; ; efferent ductule; ; vas deferens; ; gastrula; ; seminal vesicula; ; granulocyte;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; metal ion binding; protein domain specific binding; nucleotide binding; GTPase activating protein binding; guanyl nucleotide binding; GDP binding; G protein-coupled receptor binding; G-protein beta/gamma-subunit complex binding; G protein-coupled serotonin receptor binding; protein binding; GTPase activity; GTP binding;
Cellular component	extracellular exosome; lysosomal membrane; cytoplasm; microtubule organizing center; Golgi apparatus; heterotrimeric G-protein complex; membrane; centrosome; midbody; membrane raft; zymogen granule; cytoskeleton; plasma membrane; nucleus; nucleolus; Golgi membrane; endoplasmic reticulum membrane;
Biological process	cell cycle; signal transduction; negative regulation of adenylate cyclase activity; GTP metabolic process; cell division; vesicle fusion; dopamine receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; protein folding; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; transport; positive regulation of macroautophagy; G protein-coupled receptor signaling pathway; brain development; positive regulation of superoxide anion generation; positive regulation of NAD(P)H oxidase activity; positive regulation of vascular associated smooth muscle cell proliferation; negative regulation of apoptotic signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2773
	14679
	ENSG00000065135
	ENSMUSG00000000001
	P08754
	Q9DC51
	NM_006496
	NM_010306
	NP_006487
	NP_034436
	Wikidata
View/Edit Human	View/Edit Mouse

Guanine nucleotide-binding protein G(k) subunit alpha is a protein that in humans is encoded by the GNAI3 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000065135 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000001 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Didsbury JR, Snyderman R (Jul 1987). "Molecular cloning of a new human G protein. Evidence for two Gi alpha-like protein families". FEBS Letters. 219 (1): 259–63. doi:10.1016/0014-5793(87)81228-0. PMID 3109953. S2CID 85219415.
^ "Entrez Gene: GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000065135 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000001 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3109953-5] Didsbury JR, Snyderman R (Jul 1987). "Molecular cloning of a new human G protein. Evidence for two Gi alpha-like protein families". FEBS Letters. 219 (1): 259–63. doi:10.1016/0014-5793(87)81228-0. PMID 3109953. S2CID 85219415.

[entrez-6] "Entrez Gene: GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3".

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