Guanine nucleotide-binding protein G(olf) subunit alpha is a protein that in humans is encoded by the GNAL gene.[5][6] Its main product is the heterotrimeric G-protein alpha subunit Golf-α, a member of the Gs alpha subunit family that is a key component of G protein-coupled receptor-regulated adenylyl cyclase signal transduction pathways in the olfactory system and the striatum in the brain. It also mediated D1 receptor signalling in the striatum and is hence involved in motor control.[7]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000141404 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024524 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Wilkie TM, Gilbert DJ, Olsen AS, Chen XN, Amatruda TT, Korenberg JR, Trask BJ, de Jong P, Reed RR, Simon MI, et al. (Jun 1993). "Evolution of the mammalian G protein alpha subunit multigene family". Nat Genet. 1 (2): 85–91. doi:10.1038/ng0592-85. PMID 1302014. S2CID 31888533.
- ^ "Entrez Gene: GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type".
- ^ Zhuang X, Belluscio L, Hen R (15 August 2000). "GOLFα Mediates Dopamine D 1 Receptor Signaling". The Journal of Neuroscience. 20 (16): RC91. doi:10.1523/JNEUROSCI.20-16-j0001.2000. PMC 6772608. PMID 10924528.