GNAT1

GNAT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3RBQ
Identifiers
Aliases	GNAT1, CSNBAD3, GBT1, GNATR, CSNB1G, G protein subunit alpha transducin 1, HG1F
External IDs	OMIM: 139330; MGI: 95778; HomoloGene: 20084; GeneCards: GNAT1; OMA:GNAT1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 50,191,610 bp[1] End 50,197,696 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F1|9 58.86 cM Start 107,551,673 bp[2] End 107,556,911 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in choroid right lobe of liver retina retinal pigment epithelium mucosa of nose right testis left testis prefrontal cortex spinal cord C1 segment Top expressed in blastocyst neural layer of retina retinal pigment epithelium epithelium of lens iris morula embryo ciliary body outer nuclear layer conjunctival fornix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GDP binding metal ion binding acyl binding guanyl nucleotide binding G protein-coupled receptor binding protein kinase binding signal transducer activity GTP binding G-protein beta/gamma-subunit complex binding GTPase activity Cellular component cytoplasm cytosol plasma membrane photoreceptor connecting cilium soma apical plasma membrane photoreceptor disc membrane photoreceptor outer segment membrane photoreceptor outer segment heterotrimeric G-protein complex photoreceptor inner segment membrane cell projection Biological process response to light stimulus response to stimulus regulation of rhodopsin mediated signaling pathway detection of chemical stimulus involved in sensory perception of bitter taste detection of light stimulus involved in visual perception retina development in camera-type eye eye photoreceptor cell development response to light intensity negative regulation of cyclic-nucleotide phosphodiesterase activity cell population proliferation positive regulation of cyclic-nucleotide phosphodiesterase activity phototransduction cellular response to electrical stimulus signal transduction protein folding adenylate cyclase-modulating G protein-coupled receptor signaling pathway phototransduction, visible light rhodopsin mediated signaling pathway sensory perception of umami taste visual perception G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2779 14685 Ensembl ENSG00000114349 ENSMUSG00000034837 UniProt P11488 P20612 RefSeq (mRNA) NM_000172 NM_144499 NM_008140 RefSeq (protein) NP_000163 NP_653082 NP_032166 Location (UCSC) Chr 3: 50.19 – 50.2 Mb Chr 9: 107.55 – 107.56 Mb PubMed search [3] [4]
Wikidata
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Guanine nucleotide-binding protein G(t) subunit alpha-1 is a protein that in humans is encoded by the GNAT1 gene.^[5]

Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phosphodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in rods. Alternative splicing of this gene results in two transcript variants.^[5]