GNB5

GNB5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2PBI
Identifiers
Aliases	GNB5, guanine nucleotide binding protein (G protein), beta 5, GB5, G protein subunit beta 5, LADCI, IDDCA, gbeta5, HG2E
External IDs	OMIM: 604447; MGI: 101848; HomoloGene: 40714; GeneCards: GNB5; OMA:GNB5 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	52,191,392 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	75,253,158 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; endothelial cell; ; cerebellar hemisphere; ; Brodmann area 23; ; right hemisphere of cerebellum; ; left ovary; ; lateral nuclear group of thalamus; ; primary visual cortex; ; pons; ; kidney tubule;
	Top expressed in
	neural layer of retina; ; retinal pigment epithelium; ; olfactory tubercle; ; superior frontal gyrus; ; cingulate gyrus; ; globus pallidus; ; nucleus accumbens; ; cerebellar cortex; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar vermis;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	G-protein gamma-subunit binding; chaperone binding; protein binding; signal transducer activity; GTPase activity; GTPase activator activity;
Cellular component	membrane; cytosol; GTPase activator complex; photoreceptor outer segment; photoreceptor inner segment; nucleus; plasma membrane; myelin sheath; presynapse;
Biological process	positive regulation of GTPase activity; negative regulation of voltage-gated calcium channel activity; signal transduction; protein folding; dopamine receptor signaling pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	10681
	14697
	ENSG00000069966
	ENSMUSG00000032192
	O14775
	P62881
	NM_006578; NM_016194; NM_001379343
	NM_010313; NM_138719
	NP_006569; NP_057278; NP_001366272; NP_006569.1
	NP_034443; NP_619733
	Wikidata
View/Edit Human	View/Edit Mouse

Guanine nucleotide-binding protein subunit beta-5 is a protein that in humans is encoded by the GNB5 gene.^[5] Alternatively spliced transcript variants encoding different isoforms exist.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000069966 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032192 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jones PG, Lombardi SJ, Cockett MI (Jun 1998). "Cloning and tissue distribution of the human G protein beta 5 cDNA". Biochim. Biophys. Acta. 1402 (3): 288–91. doi:10.1016/S0167-4889(98)00017-2. PMID 9606987.
^ "Entrez Gene: GNB5 guanine nucleotide binding protein (G protein), beta 5".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000069966 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032192 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9606987-5] Jones PG, Lombardi SJ, Cockett MI (Jun 1998). "Cloning and tissue distribution of the human G protein beta 5 cDNA". Biochim. Biophys. Acta. 1402 (3): 288–91. doi:10.1016/S0167-4889(98)00017-2. PMID 9606987.

[entrez-6] "Entrez Gene: GNB5 guanine nucleotide binding protein (G protein), beta 5".

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