GOPC

GOPC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DC2, 2LOB, 4E34, 4E35, 4JOE, 4JOF, 4JOG, 4JOH, 4JOJ, 4JOK, 4JOP, 4JOR, 4K6Y, 4K72, 4K75, 4K76, 4K78, 4NMO, 4NMP, 4NMQ, 4NMR, 4NMS, 4NMT, 4NMV, 4Q6H, 4Q6S
Identifiers
Aliases	GOPC, CAL, FIG, GOPC1, PIST, dJ94G16.2, golgi-associated PDZ and coiled-coil motif containing, golgi associated PDZ and coiled-coil motif containing
External IDs	OMIM: 606845; MGI: 2149946; HomoloGene: 10695; GeneCards: GOPC; OMA:GOPC - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	117,602,542 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	52,258,220 bp
RNA expression pattern
	Top expressed in
	tibia; ; pancreatic epithelial cell; ; parietal pleura; ; visceral pleura; ; secondary oocyte; ; germinal epithelium; ; middle temporal gyrus; ; skin of arm; ; tendon of biceps brachii; ; Achilles tendon;
	Top expressed in
	trigeminal ganglion; ; medullary collecting duct; ; dorsomedial hypothalamic nucleus; ; piriform cortex; ; lumbar spinal ganglion; ; dentate gyrus of hippocampal formation granule cell; ; ascending aorta; ; epithelium of lens; ; right kidney; ; atrioventricular valve;
	More reference expression data
	n/a
Gene ontology
Molecular function	transmembrane transporter binding; protein binding; frizzled binding; protein C-terminus binding; GTPase regulator activity; protein homodimerization activity;
Cellular component	lysosomal membrane; Golgi-associated vesicle membrane; trans-Golgi network transport vesicle; synapse; cell projection; cell junction; Golgi membrane; postsynaptic density; postsynaptic membrane; dendrite; membrane; Golgi apparatus; cytoplasm; plasma membrane; protein-containing complex;
Biological process	endoplasmic reticulum to Golgi vesicle-mediated transport; protein homooligomerization; apical protein localization; protein transport; Golgi to plasma membrane transport; negative regulation of anion channel activity; cytoplasmic sequestering of CFTR protein; negative regulation of protein localization to cell surface; spermatid nucleus differentiation; regulation of catalytic activity;
	Sources:Amigo / QuickGO
Orthologs
	57120
	94221
	ENSG00000047932
	ENSMUSG00000019861
	Q9HD26
	Q8BH60
	NM_020399; NM_001017408
	NM_001199272; NM_053187
	NP_001017408; NP_065132
	NP_001186201; NP_444417
	Wikidata
View/Edit Human	View/Edit Mouse

Golgi-associated PDZ and coiled-coil motif-containing protein is a protein that in humans is encoded by the GOPC gene.^[5]^[6]^[7]

PIST is a PDZ domain-containing Golgi protein. PDZ domains contain approximately 90 amino acids and bind the extreme C terminus of proteins in a sequence-specific manner.[supplied by OMIM]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000047932 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019861 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Neudauer CL, Joberty G, Macara IG (Feb 2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10". Biochem Biophys Res Commun. 280 (2): 541–7. doi:10.1006/bbrc.2000.4160. PMID 11162552.
^ Yao R, Maeda T, Takada S, Noda T (Aug 2001). "Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled". Biochem Biophys Res Commun. 286 (4): 771–8. doi:10.1006/bbrc.2001.5430. PMID 11520064.
^ ^a ^b "Entrez Gene: GOPC golgi associated PDZ and coiled-coil motif containing".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000047932 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019861 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11162552-5] Neudauer CL, Joberty G, Macara IG (Feb 2001). "PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10". Biochem Biophys Res Commun. 280 (2): 541–7. doi:10.1006/bbrc.2000.4160. PMID 11162552.

[pmid11520064-6] Yao R, Maeda T, Takada S, Noda T (Aug 2001). "Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled". Biochem Biophys Res Commun. 286 (4): 771–8. doi:10.1006/bbrc.2001.5430. PMID 11520064.

[entrez-7] "Entrez Gene: GOPC golgi associated PDZ and coiled-coil motif containing".

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