GPR124

ADGRA2
Identifiers
Aliases	ADGRA2, G protein-coupled receptor 124, TEM5, GPR124, adhesion G protein-coupled receptor A2
External IDs	OMIM: 606823; MGI: 1925810; HomoloGene: 13112; GeneCards: ADGRA2; OMA:ADGRA2 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	37,844,896 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	27,613,464 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; seminal vesicula; ; canal of the cervix; ; left uterine tube; ; saphenous vein; ; body of uterus; ; gallbladder; ; right ovary; ; tail of epididymis; ; superficial temporal artery;
	Top expressed in
	umbilical cord; ; dermis; ; external carotid artery; ; Gonadal ridge; ; yolk sac; ; endocardial cushion; ; internal carotid artery; ; vas deferens; ; uterus; ; abdominal wall;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; protein binding; signal transducer activity; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; cell surface; plasma membrane; membrane; cell projection; filopodium;
Biological process	positive regulation of endothelial cell migration; G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; central nervous system development; negative regulation of vascular endothelial growth factor signaling pathway; sprouting angiogenesis; regulation of angiogenesis; endothelial cell migration; regulation of chemotaxis; angiogenesis; signal transduction; regulation of establishment of blood-brain barrier;
	Sources:Amigo / QuickGO
Orthologs
	25960
	78560
	ENSG00000020181
	ENSMUSG00000031486
	Q96PE1
	Q91ZV8
	NM_032777
	NM_054044
	NP_116166
	NP_473385
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 124 is a protein that in humans is encoded by the GPR124 gene.^[5]^[6]^[7] It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.^[8]^[9]^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000020181 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031486 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, St Croix B (September 2001). "Cell surface tumor endothelial markers are conserved in mice and humans". Cancer Research. 61 (18): 6649–6655. PMID 11559528.
^ Fredriksson R, Gloriam DE, Höglund PJ, Lagerström MC, Schiöth HB (February 2003). "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini". Biochemical and Biophysical Research Communications. 301 (3): 725–734. doi:10.1016/S0006-291X(03)00026-3. PMID 12565841.
^ "Entrez Gene: GPR124 G protein-coupled receptor 124".
^ Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
^ Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (November 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–414. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.
^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, et al. (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–1378. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000020181 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031486 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11559528-5] Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, St Croix B (September 2001). "Cell surface tumor endothelial markers are conserved in mice and humans". Cancer Research. 61 (18): 6649–6655. PMID 11559528.

[pmid12565841-6] Fredriksson R, Gloriam DE, Höglund PJ, Lagerström MC, Schiöth HB (February 2003). "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini". Biochemical and Biophysical Research Communications. 301 (3): 725–734. doi:10.1016/S0006-291X(03)00026-3. PMID 12565841.

[entrez-7] "Entrez Gene: GPR124 G protein-coupled receptor 124".

[isbn1-4419-7912-3-8] Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.

[pmid12435584-9] Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (November 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–414. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.

[pmid22333914-10] Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, et al. (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–1378. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.

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