GPR132

GPR132
Identifiers
Aliases	GPR132, G2A, G protein-coupled receptor 132
External IDs	OMIM: 606167; MGI: 1890220; HomoloGene: 8350; GeneCards: GPR132; OMA:GPR132 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.33 Start 105,049,395 bp[1] End 105,065,445 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 F1 Start 112,814,493 bp[2] End 112,831,848 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte blood bone marrow cells spleen right uterine tube lymph node appendix testicle upper lobe of left lung Top expressed in thymus mesenteric lymph nodes granulocyte blood pharynx embryo spleen gastrula lip esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process signal transduction negative regulation of G2/M transition of mitotic cell cycle G protein-coupled receptor signaling pathway G1/S transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29933 56696 Ensembl ENSG00000183484 ENSMUSG00000021298 UniProt Q9UNW8 Q9Z282 RefSeq (mRNA) NM_013345 NM_001278694 NM_001278695 NM_001278696 NM_019925 RefSeq (protein) NP_001265623 NP_001265624 NP_001265625 NP_037477 NP_064309 Location (UCSC) Chr 14: 105.05 – 105.07 Mb Chr 12: 112.81 – 112.83 Mb PubMed search [3] [4]
Wikidata
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G protein coupled receptor 132, also termed G2A, is classified as a member of the proton sensing G protein coupled receptor (GPR) subfamily. Like other members of this subfamily, i.e. GPR4, GPR68 (OGR1), and GPR65 (TDAG8), G2A is a G protein coupled receptor that resides in the cell surface membrane, senses changes in extracellular pH, and can alter cellular function as a consequence of these changes.^[5] Subsequently, G2A was suggested to be a receptor for lysophosphatidylcholine (LPC). However, the roles of G2A as a pH-sensor or LPC receptor are disputed. Rather, current studies suggest that it is a receptor for certain metabolites of the polyunsaturated fatty acid, linoleic acid.