Protein-coding gene in the species Homo sapiens
G-protein coupled receptor family C group 5 member D is a protein that in humans is encoded by the GPRC5D gene .[ 5] multiple myeloma cells and hard keratinized tissues, with low expression in normal human tissues, rendering it an appealing target for multiple myeloma cells.[ 6] [ 7] [ 8]
^ a b c GRCh38: Ensembl release 89: ENSG00000111291 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030205 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: GPRC5D G protein-coupled receptor, family C, group 5, member D" .^ "The RAIG family member, GPRC5D, is associated with hard-keratinized structures". J. Invest. Dermatol . ^ Smith EL, Harrington K, Staehr M, Masakayan R, Jones J, Long TJ, et al. (March 2019). "GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells" . Science Translational Medicine . 11 (485). doi :10.1126/scitranslmed.aau7746 . PMC 7508042 PMID 30918115 . ^ Verkleij CP, Broekmans ME, van Duin M, Frerichs KA, Kuiper R, de Jonge AV, et al. (April 2021). "Preclinical activity and determinants of response of the GPRC5DxCD3 bispecific antibody talquetamab in multiple myeloma" . Blood Advances . 5 (8): 2196–2215. doi :10.1182/bloodadvances.2020003805 . PMC 8095149 PMID 33890981 . 
