GSDMD

GSDMD
Identifiers
AliasesGSDMD, DF5L, DFNA5L, GSDMDC1, FKSG10, gasdermin D
External IDsOMIM: 617042; MGI: 1916396; HomoloGene: 12299; GeneCards: GSDMD; OMA:GSDMD - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001166237
NM_024736

NM_026960

RefSeq (protein)

NP_001159709
NP_079012

NP_081236

Location (UCSC)Chr 8: 143.55 – 143.56 MbChr 15: 75.73 – 75.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gasdermin D (GSDMD, from combination of gastro and dermato, referencing the locations where its family of proteins were originally found to be primarily expressed[5]) is a protein that in humans is encoded by the GSDMD gene on chromosome 8.[6] It belongs to the gasdermin family which is conserved among vertebrates and comprises six members in humans, GSDMA, GSDMB, GSDMC, GSDMD, GSDME (DFNA5) and DFNB59 (Pejvakin). Members of the gasdermin family are expressed in a variety of cell types including epithelial cells and immune cells. GSDMA, GSDMB, GSDMC, GSDMD and GSDME have been suggested to act as tumour suppressors.[7]

  1. ^ a b c ENSG00000104518 GRCh38: Ensembl release 89: ENSG00000278718, ENSG00000104518Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022575Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zou, Ju; Zheng, Yixiang; Huang, Yan; Tang, Daolin; Kang, Rui; Chen, Ruochan (2021). "The Versatile Gasdermin Family: Their Function and Roles in Diseases". Frontiers in Immunology. 12. doi:10.3389/fimmu.2021.751533. ISSN 1664-3224. PMC 8632255. PMID 34858408.
  6. ^ "Entrez Gene: Gasdermin D". Retrieved 2016-08-26.
  7. ^ "GSDMD gasdermin D [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov.